当前位置: X-MOL 学术Front. Mol. Biosci. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Molecular Mechanisms of Adipogenesis: The Anti-adipogenic Role of AMP-Activated Protein Kinase.
Frontiers in Molecular Biosciences ( IF 5 ) Pub Date : 2020-05-08 , DOI: 10.3389/fmolb.2020.00076
Bilal Ahmad 1 , Christopher J Serpell 2 , Isabel Lim Fong 3 , Eng Hwa Wong 4
Affiliation  

Obesity is now a widespread disorder, and its prevalence has become a critical concern worldwide, due to its association with common co-morbidities like cancer, cardiovascular diseases and diabetes. Adipose tissue is an endocrine organ and therefore plays a critical role in the survival of an individual, but its dysfunction or excess is directly linked to obesity. The journey from multipotent mesenchymal stem cells to the formation of mature adipocytes is a well-orchestrated program which requires the expression of several genes, their transcriptional factors, and signaling intermediates from numerous pathways. Understanding all the intricacies of adipogenesis is vital if we are to counter the current epidemic of obesity because the limited understanding of these intricacies is the main barrier to the development of potent therapeutic strategies against obesity. In particular, AMP-Activated Protein Kinase (AMPK) plays a crucial role in regulating adipogenesis - it is arguably the central cellular energy regulation protein of the body. Since AMPK promotes the development of brown adipose tissue over that of white adipose tissue, special attention has been given to its role in adipose tissue development in recent years. In this review, we describe the molecular mechanisms involved in adipogenesis, the role of signaling pathways and the substantial role of activated AMPK in the inhibition of adiposity, concluding with observations which will support the development of novel chemotherapies against obesity epidemics.

中文翻译:

脂肪形成的分子机制:AMP激活的蛋白激酶的抗脂肪形成作用。

肥胖症现在是一种广泛的疾病,由于其与常见的合并症如癌症,心血管疾病和糖尿病相关联,因此肥胖症的流行已成为全球关注的焦点。脂肪组织是一种内分泌器官,因此在个体的生存中起着至关重要的作用,但其功能障碍或过量与肥胖直接相关。从多能间充质干细胞到成熟脂肪细胞形成的过程是精心策划的程序,需要表达多种基因,它们的转录因子以及来自众多途径的信号传导中间体。如果我们要应对当前的肥胖症流行,那么了解所有脂肪形成的复杂性至关重要,因为对这些复杂性的有限理解是发展有效的肥胖症治疗策略的主要障碍。特别是,AMP活化蛋白激酶(AMPK)在调节脂肪形成中起着至关重要的作用-它可以说是机体中枢细胞能量调节蛋白。由于AMPK促进棕色脂肪组织的发展超过白色脂肪组织的发展,因此近年来特别关注其在脂肪组织发展中的作用。在这篇综述中,我们描述了参与脂肪形成的分子机制,信号通路的作用以及活化的AMPK在抑制肥胖中的实质性作用,
更新日期:2020-05-08
down
wechat
bug