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Label-Free Identification of Early Stages of Breast Ductal Carcinoma via Multiphoton Microscopy
Scanning ( IF 1.750 ) Pub Date : 2020-04-02 , DOI: 10.1155/2020/9670514
Zhong Chen 1 , Wenhui Guo 2 , Deyong Kang 3 , Shu Wang 4 , Liqin Zheng 1 , Gangqin Xi 1 , Yuane Lian 3 , Chuan Wang 2 , Jianxin Chen 1
Affiliation  

Breast cancer can be cured by early diagnosis. Appropriate and effective clinical treatment benefits from accurate pathological diagnosis. However, due to the lack of effective screening and diagnostic imaging methods, early stages of breast cancer often progress to malignant breast cancer. In this study, multiphoton microscopy (MPM) via two-photon excited fluorescence combined with second-harmonic generation was used for identifying the early stages of breast ductal carcinoma. The results showed differences in both cytological features and collagen distribution among normal breast tissue, atypical ductal hyperplasia, low-grade ductal carcinoma in situ, and high-grade ductal carcinoma in situ with microinvasion. Furthermore, three features extracted from the MPM images were used to describe differences in cytological features, collagen density, and basement membrane circumference in the early stages of breast ductal carcinoma. They revealed that MPM has the ability to identify early stages of breast ductal carcinoma label-free, which would contribute to the early diagnosis and treatment of breast cancer. This study may provide the groundwork for the further application of MPM in the clinic.

中文翻译:

通过多光子显微镜无标记识别早期乳腺导管癌

乳腺癌可以通过早期诊断治愈。恰当有效的临床治疗得益于准确的病理诊断。然而,由于缺乏有效的筛查和影像诊断方法,早期乳腺癌往往会发展为恶性乳腺癌。在这项研究中,通过双光子激发荧光结合二次谐波产生的多光子显微镜 (MPM) 被用于识别乳腺导管癌的早期阶段。结果显示正常乳腺组织、非典型导管增生、低级别导管原位癌和高级别导管原位癌伴微浸润的细胞学特征和胶原分布存在差异。此外,从 MPM 图像中提取的三个特征用于描述细胞学特征、胶原密度、和早期乳腺导管癌的基底膜周长。他们揭示了 MPM 具有无标记识别早期乳腺导管癌的能力,这将有助于乳腺癌的早期诊断和治疗。本研究可能为MPM在临床上的进一步应用奠定基础。
更新日期:2020-04-02
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