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Assessment of in-vivo biocompatibility evaluation of phytogenic gold nanoparticles on Wistar albino male rats.
IET Nanobiotechnology ( IF 2.3 ) Pub Date : 2020-06-01 , DOI: 10.1049/iet-nbt.2019.0116 Balashanmugam Pannerselvam 1 , Vidya Devanathadesikan 2 , Tamil Selvi Alagumuthu 3 , Swarna V Kanth 3 , Kalaichelvan Pudupalayam Thangavelu 1
IET Nanobiotechnology ( IF 2.3 ) Pub Date : 2020-06-01 , DOI: 10.1049/iet-nbt.2019.0116 Balashanmugam Pannerselvam 1 , Vidya Devanathadesikan 2 , Tamil Selvi Alagumuthu 3 , Swarna V Kanth 3 , Kalaichelvan Pudupalayam Thangavelu 1
Affiliation
Nanomedicine is an interdisciplinary approach that involves toxicology and other medicinal applications. Gold nanoparticles (AuNPs) may serve as a promising model to address the size and shape-dependent biological response because they show good biocompatibility. This study is to prepare phytosynthesis AuNPs from ten different Cassia sp. Among them, the aqueous leaf extract of C. roxburghii produced greater efficient and stable AuNPs. The AuNPs were optimised for different physicochemical conditions. Highly stable AuNPs were synthesised at pH 7.0, 37°C, 1.0 ml of C. roxburghii leaf extract and 1.0 mM concentration of HAuCl4 with the particle size of ∼50 nm and these AuNPs were stable up to 12 months. To determine the safety profile of AuNPs in-vivo, the nanoparticles were injected intravenously into male Wistar albino rats in varying dosages. The authors noticed no significant difference in body weights, haematological and biochemical parameters and the histopathological sections of all vital organs. Highest accumulation was seen in spleen and least in brain. The authors' results show that the AuNPs were biocompatible and did not produce any adverse or abnormalities in-vivo. The implications of the bioaccumulation of AuNPs need to be further studied to rule out any adverse effects on long-term exposure.
中文翻译:
评价植物性金纳米粒子对 Wistar 白化雄性大鼠的体内生物相容性评价。
纳米医学是一种涉及毒理学和其他医学应用的跨学科方法。金纳米粒子 (AuNPs) 可以作为一个有前途的模型来解决大小和形状依赖的生物反应,因为它们显示出良好的生物相容性。本研究旨在从十种不同的决明子中制备植物合成金纳米粒子。其中,刺梨的水叶提取物产生了更有效和更稳定的金纳米粒子。AuNPs 针对不同的物理化学条件进行了优化。在 pH 7.0、37°C、1.0 ml 刺梨叶提取物和 1.0 mM HAuCl4 浓度下合成了高度稳定的 AuNPs,粒径约为 50 nm,这些 AuNPs 的稳定性长达 12 个月。为了确定金纳米粒子在体内的安全性,将纳米粒子以不同剂量静脉注射到雄性 Wistar 白化病大鼠中。作者注意到体重、血液学和生化参数以及所有重要器官的组织病理学切片没有显着差异。脾脏积聚最多,脑积聚最少。作者的结果表明,AuNPs 具有生物相容性,并且在体内不会产生任何不良或异常。需要进一步研究 AuNPs 生物积累的影响,以排除对长期暴露的任何不利影响。
更新日期:2020-06-01
中文翻译:
评价植物性金纳米粒子对 Wistar 白化雄性大鼠的体内生物相容性评价。
纳米医学是一种涉及毒理学和其他医学应用的跨学科方法。金纳米粒子 (AuNPs) 可以作为一个有前途的模型来解决大小和形状依赖的生物反应,因为它们显示出良好的生物相容性。本研究旨在从十种不同的决明子中制备植物合成金纳米粒子。其中,刺梨的水叶提取物产生了更有效和更稳定的金纳米粒子。AuNPs 针对不同的物理化学条件进行了优化。在 pH 7.0、37°C、1.0 ml 刺梨叶提取物和 1.0 mM HAuCl4 浓度下合成了高度稳定的 AuNPs,粒径约为 50 nm,这些 AuNPs 的稳定性长达 12 个月。为了确定金纳米粒子在体内的安全性,将纳米粒子以不同剂量静脉注射到雄性 Wistar 白化病大鼠中。作者注意到体重、血液学和生化参数以及所有重要器官的组织病理学切片没有显着差异。脾脏积聚最多,脑积聚最少。作者的结果表明,AuNPs 具有生物相容性,并且在体内不会产生任何不良或异常。需要进一步研究 AuNPs 生物积累的影响,以排除对长期暴露的任何不利影响。