Influencing Factors of Recanalization after Intravenous Thrombolysis with Urokinase in Acute Cerebral Infarction Patients,European Neurology

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Influencing Factors of Recanalization after Intravenous Thrombolysis with Urokinase in Acute Cerebral Infarction Patients
European Neurology ( IF 2.4 ) Pub Date : 2020-01-01 , DOI: 10.1159/000507288
Jianqi Zeng ₁ , Feng Wang ₂ , Haishan Feng ₃ , Feng Chen ₄ , Ru Wang ₅ , Yiqian Chen ₁ , Xingyu Chen ₆ , Jiayin Miao ₁

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Background: Intravenous thrombolysis (IVT) with urokinase is the standard reperfusion therapy for acute cerebral infarction (ACI) in China. Only about 30% patients who use urokinase for IVT can recanalize. Therefore, this study aimed to analyze the influencing factors of recanalization after IVT using urokinase in ACI patients. Methods: A total of 391 consecutive patients with a diagnosis of ACI from January 2013 to October 2019 were enrolled and divided into 2 groups: patients without recanalization and patients with recanalization. Related data were collected and analyzed. Results: Univariate analysis showed that there were significant differences in gender, atrial fibrillation, erythrocyte mean corpuscular volume, platelet large cell ratio (P-LCR), glucose (GLU), and severity of ICAS between patients without recanalization and patients with recanalization (p < 0.05). Multivariate logistic regression analysis indicated that P-LCR (odds ratio [OR] = 0.17, 95% confidence interval [CI] = 0.03–0.89, p = 0.04), GLU (OR = 0.28, 95% CI = 0.11–0.67, p = 0.004), and ICAS severity (OR = 0.48, 95% CI = 0.32–0.76, p = 0.001) were the influencing factors of recanalization. Conclusion: For patients with higher levels of P-LCR, GLU, or ICAS severity, the recanalization rate might decrease after ACI.

更新日期：2020-01-01

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