Dexmedetomidine (DEX) is a highly selective α2 adrenergic receptor (α2AR) agonist currently used in clinical settings. Because DEX has dose-dependent advantages of sedation, analgesia, antianxiety, inhibition of sympathetic nervous system activity, cardiovascular stabilization, and significant reduction of postoperative delirium and agitation, but does not produce respiratory depression and agitation, it is widely used in clinical anesthesia and ICU departments. In recent years, much clinical study and basic research has confirmed that DEX has a protective effect on a variety of organs, including the nervous system, heart, lungs, kidneys, liver, and small intestine. It acts by reducing the inflammatory response in these organs, activating antiapoptotic signaling pathways which protect cells from damage. Therefore, based on wide clinical application and safety, DEX may become a promising clinical multiorgan protection drug in the future. In this article, we review the physiological effects related to organ protection in α2AR agonists along with the organ-protective effects and mechanisms of DEX to understand their combined application value.

中文翻译：

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右美托咪定的器官保护作用及其潜在机理。

右美托咪定（DEX）是高度选择性的α2肾上腺素能受体（α2AR）目前在临床环境中使用的激动剂。由于DEX具有镇静，镇痛，抗焦虑，抑制交感神经系统活性，心血管稳定以及显着减少术后a妄和躁动的剂量依赖性优势，但不会产生呼吸抑制和躁动，因此被广泛用于临床麻醉和ICU部门。近年来，许多临床研究和基础研究已经证实DEX对多种器官具有保护作用，包括神经系统，心脏，肺，肾脏，肝脏和小肠。它通过减少这些器官的炎症反应，激活抗凋亡信号通路来发挥作用，从而保护细胞免受损伤。因此，基于广泛的临床应用和安全性，DEX可能会在将来成为有前途的临床多器官保护药物。在本文中，我们回顾了与器官保护相关的生理效应。α与器官保护作用和DEX机制沿着2AR激动剂以了解他们的组合的应用价值。