Nasal injury following nasal surgery is an adverse consequence, and prompt treatment should be initiated. Nasal packing, either non-absorbable or absorbable, are commonly used after nasal surgery to prevent bleeding and promote wound healing. In the current study, a novel gelatine sponge crosslinked with genipin was evaluated for suitability to be used as nasal packing and compared to one of the frequently used commercial nasal packing made up of polyurethane. Gelatine at 7% and 10% (w/v) concentration were crosslinked with varying concentrations of genipin, 0.5%, 0.25%, and 0.2% (v/v). The gelatine sponges were further characterised by its water uptake ability, biodegradation, water vapour transmission rate, porosity, contact angle, chemical composition, crosslinking degree, and mechanical properties. The gelatine sponges absorbed five times more water than their dry weight and were degraded within five days. The water vapour transmission rate of the gelatine sponges was 1187.7 ± 430.2 g/(m⁻² day) for 7% gelatine and 779.4 ± 375.5 g/(m⁻² day) for 10% gelatine. Crosslinking of gelatine with genipin resulted in lower porosity and did not affect the wettability of gelatine sponge (contact angle: 95.3 ± 12.1° for 7% gelatine and 88.4 ± 7.2° for 10% gelatine). In terms of biodegradability, the gelatine sponges took 24–48 h to degrade completely. Genipin crosslinking improved the degradation resistance and mechanical strength of gelatine sponge. The physical and chemical properties of the gelatine sponge, i.e. biodegradability and mechanical durability, support its potential as nasal packing.

鼻部手术后的鼻损伤是不良后果，应立即开始治疗。鼻填塞，无论是不可吸收的还是可吸收的，通常在鼻部手术后使用，以防止出血和促进伤口愈合。在目前的研究中，评估了一种与京尼平交联的新型明胶海绵作为鼻腔填充物的适用性，并与一种常用的由聚氨酯制成的商业鼻腔填充物进行了比较。7% 和 10% (w/v) 浓度的明胶与不同浓度的京尼平交联，0.5%、0.25% 和 0.2% (v/v)。明胶海绵的进一步特征在于其吸水能力、生物降解性、水蒸气透过率、孔隙率、接触角、化学成分、交联度和机械性能。明胶海绵吸收的水分是其干重的五倍，并在五天内降解。明胶海绵的水蒸气透过率为 1187.7 ± 430.2 g/(m^-2天）对于 7% 明胶和 779.4 ± 375.5 g/（​​m ^-2天）对于 10% 明胶。明胶与京尼平的交联导致较低的孔隙率，并且不影响明胶海绵的润湿性（接触角：7% 明胶为 95.3 ± 12.1°，10% 明胶为 88.4 ± 7.2°）。在生物降解性方面，明胶海绵需要 24-48 小时才能完全降解。京尼平交联提高了明胶海绵的抗降解性和机械强度。明胶海绵的物理和化学特性，即生物降解性和机械耐久性，支持其作为鼻腔填充物的潜力。