Introduction: Obesity and associated risk factors have been linked to cognitive decline before. Objectives: In the present study, we evaluated potential cumulative negative effects of overweight and obesity on cognitive performance in euthymic patients with bipolar disorder (BD) in a longitudinal design. Methods: Neurocognitive measures (California Verbal Learning Test, Trail Making Test [TMT] A/B, Digit-Symbol-Test, Digit-Span, d2 Test), anthropometrics (e.g., body mass index [BMI]), and clinical ratings (Hamilton Depression Scale, Young Mania Rating Scale) were collected over a 12-month observation period. Follow-up data of 38 patients with BD (mean age 40 years; 15 males, 23 females) were available. Results: High baseline BMI predicted a decrease in the patient’s performance in the Digit-Span backwards task measuring working memory performance. In contrast, cognitive performance was not predicted by increases in BMI at follow-up. Normal weight bipolar patients (n = 19) improved their performance on the TMT B, measuring cognitive flexibility and executive functioning, within 1 year, while overweight bipolar patients (n = 19) showed no change in this task. Conclusions: The results suggest that overweight can predict cognitive performance changes over 12 months.
Neuropsychobiology

中文翻译：

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体重指数预测双相情感障碍的执行功能下降：12 个月随访研究的初步数据。

简介：肥胖和相关的危险因素以前与认知能力下降有关。目标：在本研究中，我们在纵向设计中评估了超重和肥胖对双相情感障碍 (BD) 情绪正常患者认知能力的潜在累积负面影响。方法：神经认知测量（加利福尼亚语言学习测试、线索制作测试 [TMT] A/B、数字符号测试、数字跨度、d2 测试）、人体测量学（例如，体重指数 [BMI]）和临床评级（在 12 个月的观察期内收集了汉密尔顿抑郁量表、年轻躁狂症评定量表）。可获得 38 名 BD 患者（平均年龄 40 岁；15 名男性，23 名女性）的随访数据。结果：高基线 BMI 预测患者在测量工作记忆性能的 Digit-Span 向后任务中的表现下降。相比之下，随访时 BMI 的增加并不能预测认知表现。正常体重的双相障碍患者 ( n = 19) 在 1 年内改善了他们在 TMT B 上的表现，测量了认知灵活性和执行功能，而超重的双相障碍患者 ( n = 19) 在这项任务中没有变化。结论：结果表明，超重可以预测 12 个月内的认知能力变化。
神经心理生物学