Hydrogel dressings have significant advantages such as absorption of tissue exudate, maintenance of proper moist environment, and promotion of cell proliferation. However, facile preparation method and high-efficient antibacterial hydrogel dressings are still a great challenge. In this study, a facile approach to prepare antibacterial nanocomposite hydrogel dressing to accelerate healing was explored. The hydrogels consisted of quaternized chitosan and chemically cross-linked polyacrylamide, as well as silver nanoparticles (AgNPs) stabilized by chitosan. The synthesis of the hydrogels including the formation of AgNPs and polymerization of acrylamide was accomplished simultaneously under UV irradiation in 1 hour without adding initiator. The hydrogels showed favorable tensile strength of ∼100 kPa with elongation at break over 1000% and shear modulus of ∼104 Pa as well as suitable swelling ratio, which were appropriate for wound dressing. The combination of quaternized chitosan and AgNPs exhibited high-efficient and synergetic antibacterial performance with low cytotoxicity. In vivo animal experiments showed that the hydrogel can effectively prevent wound infection and promote wound healing. This study provides a facile method to produce antibacterial hydrogel wound dressing materials.

中文翻译：

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一锅紫外光化学合成制备的季铵化壳聚糖/银纳米颗粒高效协同抗菌纳米复合水凝胶

水凝胶敷料具有吸收组织渗出液、维持适当湿润环境、促进细胞增殖等显着优点。然而，简便的制备方法和高效的抗菌水凝胶敷料仍然是一个巨大的挑战。在这项研究中，探索了一种制备抗菌纳米复合水凝胶敷料以加速愈合的简便方法。水凝胶由季铵化壳聚糖和化学交联聚丙烯酰胺以及由壳聚糖稳定的银纳米粒子 (AgNPs) 组成。水凝胶的合成包括 AgNPs 的形成和丙烯酰胺的聚合是在紫外线照射下在 1 小时内同时完成的，无需添加引发剂。水凝胶显示出良好的拉伸强度~100 kPa，断裂伸长率超过1000%，剪切模量~104 Pa，溶胀率合适，适用于伤口敷料。季铵化壳聚糖和 AgNPs 的组合表现出高效协同的抗菌性能和低细胞毒性。体内动物实验表明，该水凝胶能有效防止伤口感染，促进伤口愈合。该研究为生产抗菌水凝胶伤口敷料材料提供了一种简便的方法。体内动物实验表明，该水凝胶能有效防止伤口感染，促进伤口愈合。该研究为生产抗菌水凝胶伤口敷料材料提供了一种简便的方法。体内动物实验表明，该水凝胶能有效防止伤口感染，促进伤口愈合。该研究为生产抗菌水凝胶伤口敷料材料提供了一种简便的方法。