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SARS‐CoV‐2 spike glycoprotein‐binding proteins expressed by upper respiratory tract bacteria may prevent severe viral infection
FEBS Letters ( IF 3.5 ) Pub Date : 2020-06-01 , DOI: 10.1002/1873-3468.13845
Kourosh Honarmand Ebrahimi 1
Affiliation  

Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has become a major global challenge. The virus infects host cells using its spike glycoprotein (S‐protein) and has significantly higher infectivity and mortality rates among the aged population. Here, based on bioinformatic analysis, I provide evidence that some members of the upper respiratory tract (URT) commensal bacteria express viral S‐protein ‐binding proteins. Based on this analysis and available data showing a decline in the population of these bacteria in the elderly, I propose that some URT commensal bacteria hamper SARS‐CoV‐2 infectivity and that a decline in the population of these bacteria contributes to the severity of infection. Further studies should provide a better understanding of the interaction of URT bacteria and SARS‐CoV‐2, which may lead to new therapeutic approaches.

中文翻译:

上呼吸道细菌表达的SARS-CoV-2刺突糖蛋白结合蛋白可预防严重病毒感染

严重急性呼吸系统综合症冠状病毒 2 (SARS-CoV-2) 已成为一项重大的全球挑战。该病毒使用其刺突糖蛋白(S-蛋白)感染宿主细胞,并且在老年人群中具有显着更高的传染性和死亡率。在这里,基于生物信息学分析,我提供了上呼吸道 (URT) 共生细菌的一些成员表达病毒 S 蛋白结合蛋白的证据。根据这一分析和现有数据显示老年人中这些细菌的数量下降,我建议一些 URT 共生细菌阻碍了 SARS-CoV-2 的传染性,并且这些细菌的数量下降会导致感染的严重程度. 进一步的研究应该可以更好地了解 URT 细菌和 SARS-CoV-2 的相互作用,
更新日期:2020-06-01
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