Accurate surveillance of coronavirus disease 2019 (COVID-19) incidence requires large-scale testing of the population. Current testing methods require in-person collection of biospecimens by a healthcare worker, limiting access of individuals who do not have access to testing facilities while placing both the patient and healthcare worker at risk of exposure to infection. We report the development and validation of a at-home finger-prick dried blood spot collection kit and an analysis method. We demonstrated 100% sensitivity and specificity using at-home collected specimens across the US. Such methods may facilitate the conduct of unbiased serosurveys within hard to reach populations and help reduce the sample collection burden of serological testing on both health care systems and individuals alike.

中文翻译：

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一项血清学检测，以在家中收集的手指刺干的血斑中检测SARS-CoV-2抗体。

准确监测2019年冠状病毒疾病（COVID-19）发病率需要对人群进行大规模检测。当前的测试方法要求医护人员亲自收集生物标本，从而限制了无法使用测试设施的人员的访问，同时使患者和医护人员都面临感染风险。我们报告了家用手指刺干血斑采集套件和一种分析方法的开发和验证。我们在全美使用在家收集的样本证明了100％的敏感性和特异性。这样的方法可以促进难以到达的人群中进行无偏倚的血清调查，并有助于减轻卫生保健系统和个人的血清学检测的样品收集负担。