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Gap junction mediated feed-forward inhibition ensures ultra precise temporal patterning in vocal behavior
bioRxiv - Neuroscience Pub Date : 2020-05-30 , DOI: 10.1101/2020.05.27.119339
Boris P. Chagnaud , Jonathan Perelmuter , Paul Forlano , Andrew H. Bass

Precise neuronal firing is especially important for behaviors highly dependent on the correct sequencing and timing of muscle activity patterns, such as acoustic signalling. We show that extreme temporal precision in motoneuronal firing within a hindbrain network that directly determines call duration, pulse repetition rate and fundamental frequency in a teleost fish, the Gulf toadfish, depends on gap junction-mediated, feed-forward glycinergic inhibition that generates a period of reduced probability of motoneuron activation. Super-resolution microscopy confirms glycinergic release sites contacting motoneuron somata and dendrites. Synchronous motoneuron activity can also induce action potential firing in pre-motoneurons, a feature that could figure prominently into motor timing. Gap junction-mediated, feed-forward glycinergic inhibition provides a novel means for achieving temporal precision in the millisecond range for rapid modulation of an acoustic signal and perhaps other motor behaviors.

中文翻译:

间隙连接介导的前馈抑制可确保声音行为的超精确时间模式

精确的神经元放电对于高度依赖于肌肉活动模式的正确顺序和时机的行为尤其重要,例如声音信号。我们表明,后脑网络中的动脑神经元放电的极端时间精度直接决定了硬骨鱼海湾蟾蜍鱼的呼叫持续时间,脉冲重复频率和基频,取决于间隙连接介导的前馈甘氨酸抑制,从而产生一个周期运动神经元活化的可能性降低。超高分辨率显微镜证实了与运动神经元的躯体和树突接触的甘氨酸释放位点。同步运动神经元的活动也可以诱发运动前神经元的动作电位激发,这一特征可能会在运动时机中占据重要位置。间隙连接介导的
更新日期:2020-05-30
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