For several years, environmental exogenous agents, called endocrine disruptors, are suspected to interfere with the essential functions of reproduction and development in many living organisms. In this study, endocrine disruptors including five phthalates and two bisphenols contents in finished products were assayed and their estrogenic activity were measured by using the Yeast Estrogen Screen system with respect to human and trout estrogen receptors hERα and rtER_S. Independently of the estrogen receptor, only short-chain phthalates (DBP and BBP) and the two bisphenols exhibited an estrogenic activity. Besides, the risk of three end-products (agro-food, cosmetics, and pharmaceutical) was evaluated before and after forced aging. Only two cosmetics the face cream and the perfume presented a hazard which increases with aging. These results are consistent with the compounds identified by Gas chromatography-mass spectrometry. These findings confirmed that the YES system can be routinely used to evaluate the estrogenic hazards within finished products.

几年来，人们怀疑环境外源性物质（称为内分泌干扰物）会干扰许多生物体内生殖和发育的基本功能。在这项研究中，测定了最终产品中包含五种邻苯二甲酸盐和两种双酚含量的内分泌干扰物，并使用酵母雌激素筛选系统对人和鳟鱼雌激素受体hERα和rtER _S进行了测定，测定了它们的雌激素活性。。独立于雌激素受体，只有短链邻苯二甲酸酯（DBP和BBP）和两种双酚具有雌激素活性。此外，还评估了强制老化前后三种最终产品（农产品，化妆品和药品）的风险。仅有两种化妆品的面霜和香水具有随着年龄增长而增加的危害。这些结果与通过气相色谱-质谱法鉴定的化合物一致。这些发现证实，YES系统可常规用于评估成品中的雌激素危害。