Polymer-drug conjugates are currently being more widely investigated for the treatment of hypertension. In view of the above, in the first stage of our work, we used nontoxic β-cyclodextrin (β-CD) as effective, simple, inexpensive, and safe for the human body initiator for the synthesis of biocompatible and biodegradable functionalized polymers suitable for the medical and pharmaceutical applications. The obtained polymeric products were synthesized through a ring-opening polymerization (ROP) of ε-caprolactone (CL), d,l-, and l,l- lactide (LA and LLA). The chemical structures of synthesized materials were elucidated based on ¹H NMR and solid-state carbon-13 cross-polarization/magic angle spinning nuclear magnetic resonance (¹³C CP/MAS NMR) analysis, while the incorporation of β-CD molecule into the polymer chain was confirmed by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). Furthermore, molecular modeling has been applied to investigate the intrachain rigidities and chain architectures for several representative structures. The obtained and thoroughly characterized branched matrices were then used to generate the first β-cyclodextrin/biodegradable polymer/β-blocker conjugate through the successful conjugation of pindolol. The conjugates were fabricated by carbodiimide-mediated coupling reaction. The branched biodegradable materials released the drug in vitro in a sustained manner and without “burst release” and thus have the ability to treat different heart diseases.

中文翻译：

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β-环糊精和可生物降解聚酯在控制释放度方面的性能评价。

聚合物-药物缀合物目前正在被更广泛地研究用于治疗高血压。鉴于以上所述，在我们的工作的第一阶段，我们使用无毒的β-环糊精（β-CD）作为有效，简单，廉价和对人体引发剂安全的合成适用于生物相容性和可生物降解的功能化聚合物的方法。医疗和制药应用。通过ε-己内酯（CL），d，l和l，l-丙交酯（LA和LLA）的开环聚合（ROP）来合成获得的聚合物产物。基于¹阐明了合成材料的化学结构H NMR和固态碳13交叉极化/魔角旋转核磁共振（¹³C CP / MAS NMR）分析，同时通过基质辅助激光解吸/电离飞行时间质谱（MALDI-TOF MS）证实了将β-CD分子掺入聚合物链中。此外，分子建模已用于研究几种代表性结构的链内刚性和链结构。然后，将获得的且经过充分表征的分支矩阵用于通过成功地结合潘多洛尔来生成第一个β-环糊精/可生物降解的聚合物/β-阻滞剂结合物。通过碳二亚胺介导的偶联反应制备缀合物。分支的可生物降解材料以持续的方式在体外释放药物，而没有“爆发释放”，因此具有治疗各种心脏病的能力。