Several specific alterations of the extracellular matrix can be considered a distinctive hallmark of cancer. In particular, a different morphology of the collagen scaffold is frequently found within the peritumoural environment. In this study, we report about a significant difference in the ultrastructural organization of collagen at the supra‐molecular level between the perilesional scaffold and the tumour area in human breast carcinoma samples. In particular, we demonstrated that polarization‐resolved second‐harmonic generation (P‐SHG) microscopy is able to link the altered collagen architecture at the ultrastructural level found in perilesional tissue with a different organization of collagen fibrils at the molecular level.

中文翻译：

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偏振分辨第二谐波产生显微镜显示的人类乳腺癌中的胶原超微结构对称性及其恶性改变。

细胞外基质的几种特定改变可被认为是癌症的独特标志。特别地，在肿瘤周围环境中经常发现胶原支架的不同形态。在这项研究中，我们报道了人类乳腺癌样品中病灶周围支架和肿瘤区域之间在超分子水平上胶原超微结构的显着差异。特别是，我们证明了偏振分辨第二谐波（P-SHG）显微镜能够将在病变周围组织中发现的超微结构水平改变的胶原结构与分子水平上不同的胶原纤维组织联系起来。