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Evaluating the preventive and curative effects of Toxocara canis larva in Freund's complete adjuvant-induced arthritis.
Parasite Immunology ( IF 2.2 ) Pub Date : 2020-05-29 , DOI: 10.1111/pim.12760
Zahra Shayesteh 1 , Hamid Hosseini 2 , Vahid Nasiri 3 , Zeinab Haddadi 4 , Najmeh Moradi 1 , Leila Beikzadeh 4 , Monireh Sezavar 4 , Aliehsan Heidari 2 , Mohammad Zibaei 2
Affiliation  

Helminthic infection and the parallel host immune reactions are the results of a protracted dynamic co‐interaction between the host and worms. An assessment of the effect of Toxocara canis infection on arthritis in rats stimulated by Freund's complete adjuvant (FCA) was the main purpose of the investigation. An arthritis model was established by the administration of 0.1 mL FCA in the palmar surface. Cytokine assessment, evaluating oedema and the use of a rheumatoid arthritis (RA) score provided evidence of the protective effects of T canis against adjuvant‐induced arthritis (AIA). The cytokines TGF‐β, IFN‐ɣ, IL‐10 and IL‐17 were measured to assess the anti‐inflammatory effect of T canis infection. Besides, arthritis swelling findings were evaluated in rat paws. The data showed that T canis infection significantly modulated the immune response by alleviating inflammatory cytokines and increasing TGF‐β as an anti‐inflammatory cytokine. Evaluations of arthritis swelling showed low severity and faster recuperation. These findings suggest that the products derived from T canis eggs might be a potential therapeutic candidate to treat autoimmune diseases like the arthritis.

中文翻译:

评估Toxocara canis幼虫在弗氏完全佐剂诱发的关节炎中的预防和治疗效果。

蠕虫感染和并行的宿主免疫反应是宿主与蠕虫之间持久的动态相互作用的结果。研究的主要目的是评估犬弓形虫感染对弗氏完全佐剂(FCA)刺激的大鼠关节炎的影响。通过在手掌表面施用0.1 mL FCA建立关节炎模型。细胞因子评估,评估水肿和使用类风湿关节炎(RA)评分提供了T犬对佐剂性关节炎(AIA)的保护作用的证据。测量细胞因子TGF-β,IFN-γ,IL-10和IL-17来评估犬犬的抗炎作用感染。此外,评估了大鼠足爪的关节炎肿胀发现。数据显示犬T犬感染可通过减轻炎症细胞因子并增加TGF-β作为抗炎细胞因子来显着调节免疫反应。关节炎肿胀的评估显示严重程度较低且恢复更快。这些发现表明,源自犬T卵的产品可能是治疗自身免疫性疾病(如关节炎)的潜在疗法。
更新日期:2020-05-29
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