With the rapid increase in the population of obese individuals, obesity has become a global problem. Many kinds of chronic metabolic diseases easily caused by obesity have received increasing attention from researchers. People are also striving to find various safe and effective treatment methods as well as anti-obesity medicines. Pancreatic lipase (PL) inhibitors have received substantial attention from researchers in recent years, and PL inhibitors from natural products have attracted much attention due to their structural diversity, low toxicity and wide range of sources. They have been used in the intestinal tract, blood, and the central nervous system with no side effects, and these advantages could lead to a new generation of diet pills or health care products with great development potential. This article is mainly aimed at discussing the research of obesity drug treatment with PL inhibitors and offers a brief review of related properties and the use of PL inhibitors in the field of weight loss.

随着肥胖人群的迅速增加，肥胖已成为全球性问题。肥胖引起的许多慢性代谢性疾病已引起研究人员的越来越多的关注。人们也在努力寻找各种安全有效的治疗方法以及抗肥胖药。近年来，胰腺脂肪酶（PL）抑制剂受到研究人员的广泛关注，而天然产物的PL抑制剂由于其结构多样性，低毒性和来源广泛而备受关注。它们已在肠道，血液和中枢神经系统中使用，没有任何副作用，这些优势可能导致新一代减肥药或具有巨大发展潜力的保健产品。