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Compliance in subcutaneous and sublingual allergen immunotherapy: A nationwide study.
Respiratory Medicine ( IF 4.3 ) Pub Date : 2020-05-30 , DOI: 10.1016/j.rmed.2020.106039
Morten Borg 1 , Anders Løkke 2 , Ole Hilberg 2
Affiliation  

Introduction

Allergic rhino-conjunctivitis is a highly prevalent condition. In moderate to severe cases, allergen immunotherapy (AIT) is a cost-effective therapeutic option. Previous data have reported a large difference in treatment compliance of subcutaneously (SCIT) and sublingually (SLIT) administered AIT.

Methods

By use of the unique civil registration number assigned to all Danish citizens and the Danish National Health Service Prescription Database, compliance rates of all patients prescribed with grass pollen AIT from January 1998 until December 2016 were analysed annually during the three-year treatment period.

Results

The male/female ratio was close to 1:1 in SCIT, while SLIT was more frequently used by men. A large proportion of users was children or adolescents (32% and 45%, SCIT and SLIT, respectively). Compliance of both subcutaneous and sublingual treatment gradually fell each year; compliance in year 3 was 57% and 53% for subcutaneous and sublingual treatment, respectively. Compliance of grass pollen sublingual treatment was also analysed each year after registration on the Danish market. Compliance significantly increased following the introduction and stabilised on a relatively high level.

Conclusion

Based on previous studies, we hypothesised that AIT compliance would be low, especially in SLIT. However, in Denmark, compliance in SCIT and SLIT was almost similar, and the majority of patients completed the three-year treatment period with a compliance in the last quintile.



中文翻译:

皮下和舌下过敏原免疫疗法的依从性:一项全国性研究。

介绍

过敏性鼻结膜炎是一种高度流行的疾病。在中到重度病例中,过敏原免疫疗法(AIT)是一种经济有效的治疗选择。先前的数据报道皮下(SCIT)和舌下(SLIT)给予AIT的治疗依从性差异很大。

方法

通过使用分配给所有丹麦公民的唯一民用登记号和丹麦国家卫生服务处方数据库,在三年的治疗期间内,每年对1998年1月至2016年12月使用草粉AIT处方的所有患者的依从率进行分析。

结果

SCIT中的男女比例接近1:1,而SLIT在男性中使用率更高。用户中的很大一部分是儿童或青少年(分别为SCIT和SLIT的32%和45%)。皮下和舌下治疗的依从性逐年下降。皮下和舌下治疗的第三年依从性分别为57%和53%。在丹麦市场上注册后,每年还分析草花粉舌下处理的依从性。引入后,合规性显着提高,并保持在较高水平。

结论

根据以前的研究,我们假设AIT依从性较低,尤其是在SLIT中。但是,在丹麦,SCIT和SLIT的依从性几乎相似,并且大多数患者完成了三年的治疗期,最后一个五分位数符合要求。

更新日期:2020-05-30
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