Abstract Bacterial colonization in the form of biofilms on surfaces causes persistent infections and is an issue of considerable concern to healthcare providers. Thus, there is an urgent need for novel modification of antibiofilm surfaces on polymeric medical devices to inhibit pathogenic bacterial adhesion. Herein, we describe the development of water-soluble, antifouling polymers (APs) containing benzene moieties capable of anchoring to hydrophobic surfaces and hydrophilic poly (ethylene) glycol and carboxyl groups to inhibit pathogenic bacterial adhesion on polymeric medical devices. We found that the optimized APs could be facilely and controllably synthesized on and modify the surfaces of commercial hydrophobic substrates in aqueous solution, with the resulting polymer-coated surfaces capable of efficiently preventing pathogenic bacterial adhesion and subsequent bacterial colonization as precursors to biofilm formation. These results suggest the potential efficacy of the developed and optimized polymers for use as an antibiofilm platform to inhibit healthcare-associated infections on various polymer-based medical devices.

中文翻译：

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用于抑制病原菌粘附在医疗器械上的水性防污聚合物的简便合成和涂层

摘要 表面生物膜形式的细菌定植会导致持续感染，是医疗保健提供者相当关注的问题。因此，迫切需要对聚合物医疗器械上的抗生物膜表面进行新的修饰，以抑制致病细菌的粘附。在此，我们描述了含有苯部分的水溶性防污聚合物 (APs) 的开发，这些苯部分能够锚定在疏水表面和亲水性聚（乙二醇）和羧基上，以抑制致病细菌粘附在聚合物医疗器械上。我们发现优化的 APs 可以在水溶液中轻松可控地合成和修饰商业疏水性底物的表面，由此产生的聚合物涂层表面能够有效地防止病原细菌粘附和随后的细菌定植作为生物膜形成的前体。这些结果表明，开发和优化的聚合物用作抗生物膜平台以抑制各种基于聚合物的医疗设备上的医疗相关感染的潜在功效。