Objective

Trichinella or derived antigens have been suggested to be potential therapeutic agents for inflammatory bowel disease (IBD). We aimed to conduct a systematic review and meta-analysis of the available literature to estimate the effect of Trichinella or derived antigens on chemically induced IBD.

Methods

Studies were identified by searching the Cochrane Central Register of Controlled Trials, PubMed, Scopus, Web of Science, and Science Direct from inception to February 2020. We included articles written in English that investigated the effect of Trichinella infection and/or derived products in mouse models of IBD. Studies were pooled, and the combined standard mean difference (SMD) and 95% confidence interval (CI) were calculated using a random-effect or fixed-effect model.

Results

Thirteen studies were eventually included in the meta-analysis. The results indicated significant differences in the disease activity index (DAI), myeloperoxidase (MPO) activity, macroscopic inflammation score, and microscopic inflammation score between the experimental group and the control group. The anti-inflammatory cytokines interleukin (IL)-4, transforming growth factor-beta (TGF-β), IL-10 and IL-13 were significantly increased in the experimental group compared with the control group, whereas the levels of the proinflammatory cytokines interferon (IFN)-γ, IL-6, TNF-α, and IL-17 were significantly decreased. The percentage of regulatory T (Treg) cells was also significantly increased, while the level of the M1 phenotypic macrophage marker iNOS was significantly decreased and the expression of the M2 phenotypic macrophage marker Arg-1 was significantly increased.

Conclusion

Trichinella infection or derived antigens is effective for the alleviation of IBD in mouse models.

中文翻译：

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旋毛虫属的影响。或小鼠模型中化学诱导的炎症性肠病（IBD）的衍生抗原：系统评价和荟萃分析。

目的

已经建议旋毛虫或衍生的抗原是炎性肠病（IBD）的潜在治疗剂。我们旨在对现有文献进行系统的回顾和荟萃分析，以评估旋毛虫或衍生抗原对化学诱导的IBD的影响。

方法

从开始到2020年2月，通过搜索Cochrane对照试验中央登记册，PubMed，Scopus，Web of Science和Science Direct进行鉴定。我们纳入了英文文章，调查了旋毛虫感染和/或小鼠衍生产品的作用。 IBD的模型。汇总研究，并使用随机效应或固定效应模型计算合并的标准平均差（SMD）和95％置信区间（CI）。

结果

荟萃分析最终包括了十三项研究。结果表明，实验组和对照组的疾病活动指数（DAI），髓过氧化物酶（MPO）活性，宏观炎症评分和微观炎症评分存在显着差异。与对照组相比，实验组的抗炎细胞因子白介素（IL）-4，转化生长因子-β（TGF-β），IL-10和IL-13明显增加，而促炎细胞因子的水平干扰素（IFN）-γ，IL-6，TNF-α和IL-17明显降低。调节性T（Treg）细胞的百分比也显着增加，

结论

旋毛虫感染或衍生抗原可有效缓解小鼠模型中的IBD。