Candida albicans is both a member of the human mucosal microbiota and a common agent of invasive fungal disease. Systems biology approaches allow for analysis of the interactions between this fungus and its mammalian host. Framing these studies by considering how C. albicans and its host construct the niche the other occupies provides insight into how these interactions shape the ecosystems, behavior, and evolution of each organism. Here, we discuss recent work on multiscale systems biology approaches for examining C. albicans in relation to the host ecosystem to identify the emergent properties of the interactions and new variables that can be targeted for development of therapeutic strategies.

白色念珠菌既是人类粘膜微生物群的成员，也是侵袭性真菌病的常见病原体。系统生物学方法允许分析这种真菌与其哺乳动物宿主之间的相互作用。通过考虑白色念珠菌及其宿主如何构建其他人占据的生态位来构建这些研究，可以深入了解这些相互作用如何塑造每个生物体的生态系统、行为和进化。在这里，我们讨论了最近关于多尺度系统生物学方法的工作，用于检查与宿主生态系统相关的白色念珠菌，以确定相互作用的新兴特性和可用于制定治疗策略的新变量。