Coronaviruses (CoVs) are a large family of viruses that cause illness ranging from the common cold to more severe diseases such as Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS). Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) disease (COVID-19) has caused major public health crises. There have been more than 4,400,000 reported cases of COVID-2019 and more than 300,000 reported deaths to date (16/05/2020). SARS-CoV, MERS-CoV and SARS-CoV-2 have attracted widespread global attention due to their high infectivity and pathogenicity. To date, there is no specific treatment proven effective against these viral infectious diseases. Vaccination is considered one of the most effective strategies to prevent viral infections. Therefore, the development of effective vaccines against highly pathogenic coronaviruses is essential. In this review, we will briefly describe coronavirus vaccine design targets, summarize recent advances in the development of coronavirus vaccines, and highlight current adjuvants for improving the efficacy of coronavirus vaccines.

冠状病毒（CoV）是一大类病毒，可引起各种疾病，从普通感冒到更严重的疾病，例如严重急性呼吸系统综合症（SARS）和中东呼吸系统综合症（MERS）。严重急性呼吸系统综合症冠状病毒2（SARS-CoV-2）疾病（COVID-19）已引起重大的公共卫生危机。迄今为止（2019/05/16），已有超过4,400,000例COVID-2019报道病例和300,000例死亡报告。SARS-CoV，MERS-CoV和SARS-CoV-2由于其高传染性和致病性而引起了全球广泛关注。迄今为止，还没有被证明对这些病毒感染性疾病有效的治疗方法。接种疫苗被认为是预防病毒感染的最有效策略之一。因此，开发针对高致病性冠状病毒的有效疫苗至关重要。在这篇综述中，我们将简要描述冠状病毒疫苗的设计目标，总结冠状病毒疫苗开发的最新进展，并重点介绍目前用于改善冠状病毒疫苗功效的佐剂。