In 2013, The Cancer Genome Atlas (TCGA) Research Network found four novel prognostic subgroups of endometrial carcinoma: POLE/ultramutated (POLE), microsatellite-instable/hypermutated (MSI), copy-number-low/TP53-wild-type (CNL), and copy-number-highTP53-mutant (CNH). However, poor is known regarding uncommon histotypes of endometrial cancer. We aimed to assess the genetic profile of uterine carcinosarcoma (UCS) on the light of these findings. A systematic review and meta-analysis was performed through electronic databases searching (up to July 2019). All studies assessing UCS series for the TCGA classification were included. For each TCGA subgroup, pooled prevalence on the total UCS number was calculated. Four studies with 231 patients were included. Pooled prevalence of the TCGA subgroups were: 5.3% for the POLE subgroup, 7.3% for the MSI subgroup, 73.9% for the CNH subgroup, 13.5% for the CNL subgroup. The CNH subgroup predominates in UCS, while subgroups with high mutational load (POLE and MSI) are less common. UCS appears as a preferential evolution of CNH carcinomas.

2013年，癌症基因组图谱（TCGA）研究网络发现了四个新的子宫内膜癌预后亚型：POLE /超突变（POLE），微卫星不稳定/超突变（MSI），拷贝数低/ TP53-野生型（CNL ）和高拷贝数的TP53突变体（CNH）。然而，人们对子宫内膜癌的罕见组织学类型知之甚少。根据这些发现，我们旨在评估子宫癌肉瘤的遗传特征。通过电子数据库搜索（截至2019年7月）进行了系统的审查和荟萃分析。包括所有评估UCGA系列以TCGA分类的研究。对于每个TCGA子组，计算了UCS总数的合并患病率。包括231名患者的四项研究。TCGA子组的合并患病率为：POLE子组为5.3％，7。MSI子组为3％，CNH子组为73.9％，CNL子组为13.5％。CNH亚组在UCS中占主导地位，而突变负荷较高的亚组（POLE和MSI）则较少见。UCS似乎是CNH癌的优先进化。