The foaming behavior of poly(ε-caprolactone)/poly (lactic-co-glycolic acid) (PCL/PLGA) blends and the effect of composition on porous structure, compression property and biocompatibility are investigated. Various portions of PLGA are added into matrix PCL at dispersion phase by melt blending. A solid-state batch foaming process is used based on supercritical CO₂ as a physical blowing agent. With the PLGA content increased from 5 to 30 wt%, storage modulus and complex viscosity of PCL from rheological tests are improved significantly. Foaming tests reveal that incorporation of PLGA facilitates foaming of PCL by increasing viscosity. With an increase of PLGA content, pore size clearly decreases, and the open–cell content first increases and then decreases slightly. The maximum open-cell content value is greater than 86% for foamed 10 wt% PLGA. Moreover, uni-axial compression testing shows that dispersed PLGA improves the compressive stress distinctly. Cell structure evolutions at linear elasticity, plateau, and densification stages in compression tests are also investigated. Cell viability results demonstrate that there are more and denser live HUVECs detected on scaffold with increase of PLGA content. Compression strength of PCL/PLGA scaffold has more contributions to cell viability than that of porosity and open-cell content.

研究了聚（ε-己内酯）/聚（乳酸-乙醇酸共聚物）（PCL / PLGA）共混物的发泡行为以及组成对多孔结构，压缩性能和生物相容性的影响。通过熔融共混将PLGA的各个部分在分散相中添加到基质PCL中。基于超临界CO _2的固态间歇发泡工艺作为物理发泡剂。随着PLGA含量从5 wt％增加到30 wt％，流变试验得出的PCL的储能模量和复数粘度显着提高。发泡测试表明，加入PLGA可以通过增加粘度来促进PCL发泡。随着PLGA含量的增加，孔径明显减小，开孔含量首先增加，然后略有减少。对于发泡的10重量％的PLGA，最大开孔含量值大于86％。此外，单轴压缩试验表明，分散的PLGA明显改善了压缩应力。还研究了压缩测试中线性弹性，平稳和致密化阶段的细胞结构演变。细胞活力结果表明，随着PLGA含量的增加，在支架上检测到更多且更密集的活HUVEC。