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Oxaliplatin-induced peripheral neuropathy: clinical features, mechanisms, prevention and treatment.
Journal of Neurology ( IF 6 ) Pub Date : 2020-05-30 , DOI: 10.1007/s00415-020-09942-w
Lumei Kang 1, 2 , Yuyang Tian 2, 3 , Shilin Xu 2, 3 , Hongping Chen 2, 3
Affiliation  

Oxaliplatin (OXA) is a commonly used platinum-based chemotherapy drug for colorectal cancer. OXA-induced peripheral neurotoxcity (OIPN) is a comprehensive adverse reaction of OXA. OIPN can be divided into acute and chronic types according to clinical features and different mechanisms. The main clinical features of acute OIPN are cold-sensitive sensory symptoms and neuropathic pain in limbs. In addition to the above symptoms, chronic OIPN also produces autonomic nerve dysfunction. The most important mechanism involved in acute OIPN is the alteration of voltage-gated Na + channels, and nuclear DNA damage in chronic OIPN. There are some methods like reducing exposure to cold, calcium and magnesium salts, amifostine could be beneficial in acute OIPN prevention and dose modification, changing in schedule glutathione, duloxetine, selective serotonin reuptake inhibitors, carbonic anhydrase inhibitor in chronic OIPN prevention. Recent updates are provided in this article in relation to the clinical features, potential mechanisms, prevention and treatment of OIPN.



中文翻译:

奥沙利铂诱导的周围神经病变:临床特征、机制、预防和治疗。

奥沙利铂(OXA)是一种常用的治疗结直肠癌的铂类化疗药物。OXA 诱导的外周神经毒性(OIPN)是 OXA 的综合不良反应。OIPN根据临床特点和机制不同可分为急性型和慢性型。急性OIPN的主要临床特征是冷敏感感觉症状和四肢神经性疼痛。除上述症状外,慢性OIPN还会产生自主神经功能障碍。急性 OIPN 中最重要的机制是电压门控 Na + 通道的改变和慢性 OIPN 中的核 DNA 损伤。有一些方法,如减少接触寒冷、钙和镁盐,氨磷汀可能有益于急性 OIPN 预防和剂量调整,改变时间表谷胱甘肽、度洛西汀、选择性 5-羟色胺再摄取抑制剂,慢性 OIPN 预防中的碳酸酐酶抑制剂。本文提供了有关 OIPN 的临床特征、潜在机制、预防和治疗的最新更新。

更新日期:2020-05-30
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