Chronic obstructive pulmonary disease (COPD) increases postoperative morbidity and is associated with diminished long-term survival after lung cancer resection. Whether this is also true for mild-to-moderate COPD is uncertain. We conducted a retrospective analysis of all the patients who underwent lung cancer surgery between 2002 and 2012 in a university-affiliated hospital. The severity of airflow limitation was stratified according to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) from stage 1 to 4. Data from 1456 cases of lung cancer surgery were reviewed and 1126 patients were included in the study: 672 (59.7%) patients had COPD (GOLD 1, n = 340; GOLD 2, n = 282; GOLD 3, n = 50) and 454 patients had a normal spirometry (controls). Following lung cancer resection, patients with COPD had a higher rate of postoperative morbidities of any kind (p < 0.0001), in particular, pneumonia (7.0% vs. 3.7%; p = 0.0251) and prolonged air leak (17.0% vs. 8.2%; p < 0.0001) than controls. In-hospital mortality was increased in GOLD 3 COPD but the incidence of other postoperative complications was not influenced by COPD severity. Neither COPD nor its severity influenced long-term survival in this population. To conclude, patients with COPD undergoing lung cancer surgery were at higher risk of postoperative complications than patients with normal respiratory function but the procedure was considered safe. The presence of COPD itself did not influence long-term survival. The results of our study apply mainly to patients with a GOLD 1 and 2 COPD since only a small number of patients with GOLD 3 COPD were involved.

慢性阻塞性肺疾病（COPD）会增加术后发病率，并与肺癌切除术后的长期生存期减少有关。对于轻度至中度COPD是否同样如此还不确定。我们对某大学附属医院2002年至2012年间所有接受过肺癌手术的患者进行了回顾性分析。根据全球慢性阻塞性肺疾病倡议（GOLD）从1阶段到4阶段对气流受限的严重程度进行了分层。该研究回顾了1456例肺癌手术的数据，并纳入了1126例患者的研究：672（59.7％） COPD患者（GOLD 1，n = 340; GOLD 2，n = 282; GOLD 3，n= 50），有454例肺活量检查正常（对照）。肺癌切除后，COPD患者的任何类型的术后发病率均较高（p <0.0001），尤其是肺炎（7.0％vs. 3.7％；p = 0.0251）和长时间的漏气（17.0％vs. 8.2）。 ％; p<0.0001）。GOLD 3 COPD的院内死亡率增加，但其他术后并发症的发生率不受COPD严重程度的影响。COPD及其严重程度均未影响该人群的长期生存。总而言之，接受肺癌手术的COPD患者比具有正常呼吸功能的患者发生术后并发症的风险更高，但该过程被认为是安全的。COPD本身的存在并不影响长期生存。我们的研究结果主要适用于GOLD 1和2 COPD的患者，因为仅涉及GOLD 3 COPD的少数患者。