Abstract

Methamphetamine‐associated cardiomyopathy (MACM) is an increasingly recognized disease entity in the context of a rapidly spreading methamphetamine epidemic. MACM may afflict individuals with a wide range of ages and socioeconomic backgrounds. Presentations can vary greatly and may involve several complications unique to the disease. Given the public health significance of this disease, there is a relative dearth of consensus material to guide clinicians in understanding, diagnosing, and managing MACM. This review therefore aims to: (1) describe pathologic mechanisms of methamphetamine as they pertain to the development, progression, and prognosis of MACM, and the potential to recover cardiac function; (2) summarize existing data from epidemiologic studies and case series in an effort to improve recognition and diagnosis of the disease; (3) guide short‐ and long‐term management of MACM with special attention to expected or potential sequelae of the disease; and (4) highlight pivotal unanswered questions in need of urgent investigation from a public health perspective.

中文翻译：

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甲基苯丙胺相关性心肌病的临床特征和治疗：最新研究。

摘要

甲基苯丙胺相关的心肌病（MACM）是在快速传播的甲基苯丙胺流行病背景下日益受到认可的疾病实体。 MACM可能会折磨年龄和社会经济背景各异的人。表现可能差异很大，可能涉及该疾病独特的几种并发症。考虑到该疾病对公共卫生的重要性，目前尚缺乏相对共识的材料来指导临床医生理解，诊断和管理MACM。因此，本综述旨在：（1）描述甲基苯丙胺的病理机制，因为它们与肝素的发生，发展和预后有关。MACM，以及恢复心脏功能的潜力；（2）总结流行病学研究和病例系列的现有数据，以提高对疾病的认识和诊断；（3）指导短期和长期管理MACM特别注意该疾病的预期或潜在后遗症；（4）从公共卫生角度突出需要紧急调查的关键性未解决问题。