A new, cyclic carbonate eudesmane-type sesquiterpene, eudesmacarbonate (1), was isolated from marine filamentous cyanobacterial mats associated with apparent ingestion-related intoxications of captive bottlenose dolphins in the Florida Keys. Sequencing of 16S rDNA revealed that mats were composed of closely related Oscillatoriacean species including a previously undocumented species of Neolyngbya. The structure of 1 was elucidated by (+)-HRESIMS, 1D and 2D NMR, single-crystal X-ray diffraction, and vibrational circular dichroism data. Toxicity of 1 was assessed in the zebrafish embryo/larval model, and 1 was found to exhibit effects qualitatively similar to those observed for the known neurotoxin brevetoxin-2 and consistent with neurobehavioral impairment.

中文翻译：

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Eudesmacarbonate，一种来自佛罗里达群岛海洋丝状蓝藻垫（Oscillatoriales）的 Eudesmane 型倍半萜烯。

一种新的环状碳酸酯 eudesmane 型倍半萜烯，eudesmacarbonate ( 1 )，是从与佛罗里达群岛圈养宽吻海豚明显摄入相关中毒相关的海洋丝状蓝藻垫中分离出来的。16S rDNA 测序显示，垫子由密切相关的 Oscillatoriacean 物种组成，包括以前未记录的Neolyngbya物种。通过(+)-HRESIMS、一维和二维核磁共振、单晶X射线衍射和振动圆二色性数据阐明了1的结构。在斑马鱼胚胎/幼虫模型中评估了1 的毒性，而1 被发现表现出与已知神经毒素 brevetoxin-2 观察到的效果相似的效果，并且与神经行为障碍一致。