The hippocampus processes both spatial-temporal information and emotionally salient experiences. To test the functional properties of discrete sets of cells in the dorsal dentate gyrus (dDG), we examined whether chronic optogenetic reactivation of these ensembles was sufficient to modulate social behaviors in mice. We found that chronic reactivation of dDG cells in male mice was sufficient to enhance social behaviors in a female exposure task when compared to pre-stimulation levels. However, chronic reactivation of these cells was not sufficient to modulate group differences in a separate subset of social behaviors, and multi-region analysis of neural activity did not yield detectable differences in immediate-early gene expression or neurogenesis, suggesting a dissociation between our chronic stimulation-induced behavioral effects and underlying neural responses. Together, our results demonstrate that chronic optogenetic stimulation of cells processing valent experiences enduringly and unidirectionally modulates social interactions between male and female mice.

中文翻译：

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海马体的慢性光遗传学刺激可变地调节小鼠的社交行为

海马处理时空信息和情感上的显着体验。为了测试背齿状回（dDG）中细胞离散集的功能特性，我们检查了这些集合的慢性光遗传学激活是否足以调节小鼠的社交行为。我们发现，与刺激前水平相比，雄性小鼠中dDG细胞的慢性再激活足以增强雌性暴露任务中的社交行为。但是，这些细胞的慢性激活不足以调节社会行为的一个单独子集中的群体差异，并且对神经活动的多区域分析在早期早期基因表达或神经发生方面没有产生可检测的差异，提示我们的慢性刺激诱发的行为效应与潜在的神经反应之间没有联系。在一起，我们的研究结果表明，慢性光遗传学刺激细胞持久地处理单价经历，并单向调节雄性和雌性小鼠之间的社交互动。