Scientific studies report crucial impacts of biomechanical effectors to modulate wound healing either by scarring or regeneration. Further, the biological decision to predominantly favor the former is still cryptic. Real-time visualization of biomechanical manifestations in situ in scarring is hence necessary. Endorsed by nanostructural testing, synthetic phantom analysis, and computational simulations, we found strong mechanobiological correlates for Swept Source Optical Coherence Tomography (SS-OCT) speckles in mice cutaneous repair (full-thickness) up to 10 months. The theoretical basis of the optomechanics to provide insights into scar form-factor and evolution is proposed. Optomechanical changes have been considered as the resultant of intrinsic (e.g. fiber elastic modulus) and gross tissue mechanics (extracellular matrix (ECM)) in maturing scars. Non-invasive optomechanics supported with microscopic findings reveal scar's cross-sectional self-organizing di-fork architecture. Dual-compartment heterogeneity of di-fork exhibits stress-evading features with a dichotomy in inhabitant cellular stress-fiber distributions. This differential interactivity of scar with adjoining tissues reflects its architectural intelligence to compensate tissue loss (hypodermis/muscle) by assembling into a di-fork. Gradual establishment of baseline shifted lasting mechanobiological steady-state, later in scarring, expose scar as an alternate stable state within the skin.

中文翻译：

---

光学相干断层扫描揭示了小鼠皮肤瘢痕的自组织双叉结构。

科学研究报告了生物力学效应器通过疤痕形成或再生来调节伤口愈合的关键作用。此外，主要赞成前者的生物学决定仍然是个谜。因此，有必要在瘢痕形成的原位实时显示生物力学表现。通过纳米结构测试，合成体模分析和计算模拟，我们发现了长达10个月的小鼠皮肤修复（全层）扫掠源光学相干断层扫描（SS-OCT）斑点具有很强的力学生物学相关性。提出了光力学的理论基础，以提供有关疤痕形状因数和演变的见解。光机械的变化被认为是内在的结果（例如 纤维弹性模量）和成熟的疤痕中的总组织力学（细胞外基质（ECM））。显微镜下发现的非侵入性光力学揭示了疤痕的横截面自组织双叉结构。Di-fork的双室异质性表现出规避应力的特性，并在居民细胞的应力纤维分布上产生了二分法。疤痕与相邻组织的这种不同的交互作用反映了其结构智能，可以通过组装成双叉来补偿组织损失（皮下/肌肉）。逐渐建立的基线转移了持久的力学生物学稳态，后来形成了疤痕，使疤痕暴露为皮肤内的另一种稳定状态。Di-fork的双室异质性表现出规避应力的特性，并在居民细胞的应力纤维分布上产生了二分法。疤痕与相邻组织的这种不同的交互作用反映了其结构智能，可以通过组装成双叉来补偿组织损失（皮下/肌肉）。逐渐建立的基线移动了持久的机械生物学稳态，后来形成了疤痕，使疤痕暴露为皮肤内的另一种稳定状态。Di-fork的双室异质性表现出规避应力的特性，并在居民细胞的应力纤维分布上产生了二分法。疤痕与相邻组织的这种不同的交互作用反映了其结构智能，可以通过组装成双叉来补偿组织损失（皮下/肌肉）。逐渐建立的基线转移了持久的力学生物学稳态，后来形成了疤痕，使疤痕暴露为皮肤内的另一种稳定状态。