Bgee is a database to retrieve and compare gene expression patterns in multiple animal species, produced by integrating multiple data types (RNA-Seq, Affymetrix, in situ hybridization, and EST data). It is based exclusively on curated healthy wild-type expression data (e.g., no gene knock-out, no treatment, no disease), to provide a comparable reference of normal gene expression. Curation includes very large datasets such as GTEx (re-annotation of samples as "healthy" or not) as well as many small ones. Data are integrated and made comparable between species thanks to consistent data annotation and processing, and to calls of presence/absence of expression, along with expression scores. As a result, Bgee is capable of detecting the conditions of expression of any single gene, accommodating any data type and species. Bgee provides several tools for analyses, allowing, e.g., automated comparisons of gene expression patterns within and between species, retrieval of the prefered conditions of expression of any gene, or enrichment analyses of conditions with expression of sets of genes. Bgee release 14.1 includes 29 animal species, and is available at https://bgee.org/ and through its Bioconductor R package BgeeDB.

中文翻译：

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Bgee套件：整合了动物的精选表达谱和比较转录组学

Bgee是一个数据库，可通过整合多种数据类型（RNA-Seq，Affymetrix，原位杂交和EST数据）来检索和比较多种动物的基因表达模式。它仅基于精选的健康野生型表达数据（例如，无基因敲除，无治疗，无疾病），以提供正常基因表达的可比参考。策展包括非常大的数据集，例如GTEx（将样本重新注释为“健康”或“不健康”）以及许多小的数据集。由于一致的数据注释和处理，表达的存在/不存在以及表达得分的调用，数据得以整合并在物种之间具有可比性。结果，Bgee能够检测任何单个基因的表达条件，并容纳任何数据类型和种类。Bgee提供了几种分析工具，例如，可以自动比较物种内部和物种之间的基因表达模式，检索任何基因的优选表达条件或利用基因集表达对条件进行富集分析。Bgee版本14.1包含29种动物，可从https://bgee.org/或通过其Bioconductor R软件包BgeeDB获得。