Crohn's Disease Differentially Affects Region-Specific Composition and Aerotolerance Profiles of Mucosally Adherent Bacteria.,Inflammatory Bowel Diseases

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Crohn's Disease Differentially Affects Region-Specific Composition and Aerotolerance Profiles of Mucosally Adherent Bacteria.
Inflammatory Bowel Diseases ( IF 4.9 ) Pub Date : 2020-05-29 , DOI: 10.1093/ibd/izaa103
Nur M Shahir _{1,

2,

3} , Jeremy R Wang ₂ , E Ashley Wolber ₄ , Matthew S Schaner ₄ , Daniel N Frank ₅ , Diana Ir ₅ , Charles E Robertson ₅ , Nicole Chaumont ₆ , Timothy S Sadiq ₆ , Mark J Koruda ₆ , Reza Rahbar ₇ , B Darren Nix ₈ , Rodney D Newberry ₈ , R Balfour Sartor _{3,

4} , Shehzad Z Sheikh _{2,

3,

4} , Terrence S Furey _{2,

3,

9,

10}

Affiliation

Curriculum in Bioinformatics and Computational Biology, University of North Carolina (UNC) at Chapel Hill, Chapel Hill, North Carolina, USA.
Department of Genetics, UNC at Chapel Hill, Chapel Hill, North Carolina, USA.
Center for Gastrointestinal Biology and Disease, UNC at Chapel Hill, Chapel Hill, North Carolina, USA.
Department of Medicine, UNC at Chapel Hill, Chapel Hill, North Carolina, USA.
Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Department of Surgery, UNC at Chapel Hill, Chapel Hill, North Carolina, USA.
Department of Surgery, REX Healthcare of Wakefield, Wakefield, North Carolina, USA.
Division of Gastroenterology, John T. Milliken Department of Medicine, Washington University in St. Louis, School of Medicine, St. Louis, Missouri, USA.
Lineberger Comprehensive Cancer Center, UNC at Chapel Hill, Chapel Hill, North Carolina, USA.
Department of Biology, UNC at Chapel Hill, Chapel Hill, North Carolina, USA.

The intestinal microbiota play a key role in the onset, progression, and recurrence of Crohn disease (CD). Most microbiome studies assay fecal material, which does not provide region-specific information on mucosally adherent bacteria that directly interact with host systems. Changes in luminal oxygen have been proposed as a contributor to CD dybiosis.

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