Two novel milbemycin derivatives, 5,27-epoxy-13α-hydroxy milbemycin β₁₁ (1) and 5,27-epoxy-13α-hydroxy-25-ethyl milbemycin β₁₁ (2), were isolated from the genetically engineered strain Streptomyces avermitilis AVE-H39. Their structures were elucidated through the interpretation of HR-ESIMS and extensive NMR spectroscopic data. Compounds 1 and 2 exhibited moderate acaricidal and nematicidal activities.

中文翻译：

---

基因工程菌株阿维链霉菌AVE-H39的两种新型米尔倍霉素衍生物。

两个新的米尔倍霉素衍生物，5,27 -环氧-13 α -羟基米尔倍霉素β ₁₁（1）和5,27环氧13 α -羟基-25-乙基密尔伯霉素β ₁₁（2），从该基因工程化菌株中分离阿维链霉菌AVE-H39。通过解释HR-ESIMS和大量NMR光谱数据阐明了它们的结构。化合物1和2表现出中等的杀螨和杀线虫活性。