Voluhemins, new inhibitors of sterol O-acyltransferase, produced by Volutella citrinella BF-0440.,The Journal of Antibiotics

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Voluhemins, new inhibitors of sterol O-acyltransferase, produced by Volutella citrinella BF-0440.
The Journal of Antibiotics ( IF 3.3 ) Pub Date : 2020-05-29 , DOI: 10.1038/s41429-020-0327-0
Taichi Ohshiro _{1,

2,

3} , Haruka Morita ₁ , Elyza Aiman Azizah Nur ₁ , Kanji Hosoda _{1,

2} , Ryuji Uchida ₄ , Hiroshi Tomoda _{1,

2}

Affiliation

New compounds, designated voluhemins A (1) and B (2), are isolated from the culture broth of the fungal strain Volutella citrinella BF-0440 along with structurally related known NK12838 (3). Spectroscopic data, including 1D and 2D NMR, elucidated their structures. Compounds 1–3 have a common indoline-diterpene core and two additional isoprenyl moieties. Compounds 1 and 3 contain a hemiaminal unit, while 2 is O-methylated 1. Their inhibitory activities toward sterol O-acyltransferase (SOAT) 1 and 2 isozymes in SOAT1- and SOAT2-expressing Chinese hamster ovary (CHO) cells show that 2 selectively inhibits the SOAT2 isozyme.

更新日期：2020-05-29

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