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Megahertz single-particle imaging at the European XFEL
Communications Physics ( IF 5.5 ) Pub Date : 2020-05-29 , DOI: 10.1038/s42005-020-0362-y
Egor Sobolev , Sergei Zolotarev , Klaus Giewekemeyer , Johan Bielecki , Kenta Okamoto , Hemanth K. N. Reddy , Jakob Andreasson , Kartik Ayyer , Imrich Barak , Sadia Bari , Anton Barty , Richard Bean , Sergey Bobkov , Henry N. Chapman , Grzegorz Chojnowski , Benedikt J. Daurer , Katerina Dörner , Tomas Ekeberg , Leonie Flückiger , Oxana Galzitskaya , Luca Gelisio , Steffen Hauf , Brenda G. Hogue , Daniel A. Horke , Ahmad Hosseinizadeh , Vyacheslav Ilyin , Chulho Jung , Chan Kim , Yoonhee Kim , Richard A. Kirian , Henry Kirkwood , Olena Kulyk , Jochen Küpper , Romain Letrun , N. Duane Loh , Kristina Lorenzen , Marc Messerschmidt , Kerstin Mühlig , Abbas Ourmazd , Natascha Raab , Andrei V. Rode , Max Rose , Adam Round , Takushi Sato , Robin Schubert , Peter Schwander , Jonas A. Sellberg , Marcin Sikorski , Alessandro Silenzi , Changyong Song , John C. H. Spence , Stephan Stern , Jolanta Sztuk-Dambietz , Anthon Teslyuk , Nicusor Timneanu , Martin Trebbin , Charlotte Uetrecht , Britta Weinhausen , Garth J. Williams , P. Lourdu Xavier , Chen Xu , Ivan A. Vartanyants , Victor S. Lamzin , Adrian Mancuso , Filipe R. N. C. Maia

The emergence of high repetition-rate X-ray free-electron lasers (XFELs) powered by superconducting accelerator technology enables the measurement of significantly more experimental data per day than was previously possible. The European XFEL is expected to provide 27,000 pulses per second, over two orders of magnitude more than any other XFEL. The increased pulse rate is a key enabling factor for single-particle X-ray diffractive imaging, which relies on averaging the weak diffraction signal from single biological particles. Taking full advantage of this new capability requires that all experimental steps, from sample preparation and delivery to the acquisition of diffraction patterns, are compatible with the increased pulse repetition rate. Here, we show that single-particle imaging can be performed using X-ray pulses at megahertz repetition rates. The results obtained pave the way towards exploiting high repetition-rate X-ray free-electron lasers for single-particle imaging at their full repetition rate.



中文翻译:

欧洲XFEL的兆赫单粒子成像

由超导加速器技术驱动的高重复频率X射线自由电子激光器(XFEL)的出现使得每天测量的实验数据比以前可能的多得多。预计欧洲XFEL每秒可提供27,000个脉冲,比任何其他XFEL多两个数量级。增加的脉冲频率是单粒子X射线衍射成像的关键使能因素,它依赖于平均来自单个生物粒子的弱衍射信号。要充分利用这一新功能,需要从样品制备和输送到衍射图样采集的所有实验步骤都与增加的脉冲重复频率兼容。这里,我们显示可以使用兆赫兹重复频率的X射线脉冲执行单粒子成像。获得的结果为开发高重复率X射线自由电子激光器以其全重复率铺平了道路。

更新日期:2020-05-29
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