当前位置: X-MOL 学术J. Coord. Chem. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Synthesis and in vitro anticancer properties of a new La(III) coordination polymer
Journal of Coordination Chemistry ( IF 1.9 ) Pub Date : 2020-05-29
Xinyu Hao, Yan Li, Xiaoyi Liu, Jing’ao Ren, Conghao Shi, Yuanhui Liu, Dengfeng Zou, Qiaoyun Li, Gaowen Yang

{La(pytza)3(H2O)2·2H2O}n derived from 5-(4-pyridyl)tetrazole-2-acetic acid (Hpytza) has been synthesized by a solvothermal reaction of Hpytza and La(NO3)3·6H2O. In this compound, neighboring La3+ ions are doubly bridged by two pytza ligands in a μ1,3-COO syn-syn mode to form a binuclear unit, then adjacent binuclear units are doubly bridged to give a 1-D ladder-like chain. In vitro MTT assay on HeLa cells demonstrates that Hpytza is nontoxic while {La(pytza)3(H2O)2·2H2O}n has a low half inhibitory concentration (IC50) of 18.2 μg/mL. Furthermore, cell migration across a 2-D artificial gap indicates that this compound can effectively inhibit the migration of HeLa cells, suggesting its potential to interfere with the tumor metastasis in vivo.



中文翻译:

新型La(III)配位聚合物的合成及体外抗癌性能

由5-(4-吡啶基)四唑-2-乙酸(Hpytza)衍生的{La(pytza)3(H 2 O)2 ·2H 2 O} n已通过Hpytza和La(NO 3)的溶剂热反应合成。)3 ·6H 2 O.在此化合物中,相邻的La 3+离子被双重由两个pytza配体的桥连μ 1,3- -COO顺-顺式模式,以形成双核单元,那么相邻的双核单元双桥联,得到一维梯形链。HeLa细胞的体外MTT分析表明,Hpytza无毒,而{La(pytza)3(H 2 O)2 ·2H 2 O} n的低半数抑制浓度(IC 50)为18.2μg/ mL。此外,细胞跨越2-D人工间隙的迁移表明该化合物可以有效抑制HeLa细胞的迁移,表明其在体内干扰肿瘤转移的潜力。

更新日期:2020-05-29
down
wechat
bug