The activation of the nuclear factor-κB (NF-κB) pathway plays a central role in the initiation and progression of inflammation, which contributes to the pathogenesis and progression of various human diseases including kidney, brain, and other diseases. Tissue plasminogen activator (tPA), a serine protease regulating homeostasis of blood coagulation, fibrinolysis, and matrix degradation, has been shown to act as a cytokine to trigger profound receptor-mediated intracellular events, modulate the NF-κB pathway, and mediate organ dysfunction and injury. In this review, we focus on the current understanding of NF-κB and tPA signaling in the development and progression of kidney disease. Their roles in the nervous and cardiovascular system are also briefly discussed.

中文翻译：

---

肾脏和其他疾病中的NF-κB和tPA信号传导。

核因子-κB（NF-κB）途径的激活在炎症的发生和发展中起着核心作用，这有助于各种人类疾病（包括肾脏，脑和其他疾病）的发病和发展。组织纤溶酶原激活剂（tPA）是一种调节血液凝结，纤维蛋白溶解和基质降解稳态的丝氨酸蛋白酶，已被证明是一种细胞因子，可触发深刻的受体介导的细胞内事件，调节NF-κB通路并介导器官功能障碍和伤害。在这篇综述中，我们专注于目前对肾脏疾病的发展和进展中NF-κB和tPA信号传导的理解。还简要讨论了它们在神经和心血管系统中的作用。