In recent decades, cancer has been one of the leading causes of death worldwide. Despite advances in understanding the molecular basis of tumorigenesis, diagnosis, and clinical therapies, the discovery and development of effective drugs is an active and vital field in cancer research. Tetrahydrocurcumin is a major curcuminoid metabolite of curcumin, naturally occurring in turmeric. The interest in tetrahydrocurcumin research is increasing because it is superior to curcumin in its solubility in water, chemical stability, bioavailability, and anti-oxidative activity. Many in vitro and in vivo studies have revealed that tetrahydrocurcumin exerts anti-cancer effects through various mechanisms, including modulation of oxidative stress, xenobiotic detoxification, inflammation, proliferation, metastasis, programmed cell death, and immunity. Despite the pharmacological similarities between tetrahydrocurcumin and curcumin, the structure of tetrahydrocurcumin determines its distinct and specific molecular mechanism, thus making it a potential candidate for the prevention and treatment of cancers. However, the utility of tetrahydrocurcumin is yet to be evaluated as only limited pharmacokinetic and oral bioavailability studies have been performed. This review summarizes research on the anti-cancer properties of tetrahydrocurcumin and describes its mechanisms of action.

中文翻译：

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四氢姜黄素的癌症化学预防和治疗潜力。

在最近几十年中，癌症一直是全球范围内主要的死亡原因之一。尽管在了解肿瘤发生，诊断和临床疗法的分子基础方面取得了进步，但有效药物的发现和开发仍是癌症研究中一个活跃而至关重要的领域。四氢姜黄素是姜黄素中主要的姜黄素类代谢产物，天然存在于姜黄中。由于四氢姜黄素在水中的溶解度，化学稳定性，生物利用度和抗氧化活性优于姜黄素，因此对四氢姜黄素的研究兴趣日益增加。许多体外和体内研究表明，四氢姜黄素通过多种机制发挥抗癌作用，包括调节氧化应激，异种生物排毒，炎症，增殖，转移，程序性细胞死亡和免疫力。尽管四氢姜黄素和姜黄素在药理学上相似，但四氢姜黄素的结构决定了其独特的分子机制，因此使其成为预防和治疗癌症的潜在候选者。然而，由于仅进行了有限的药代动力学和口服生物利用度研究，因此尚未评估四氢姜黄素的效用。这篇综述总结了关于四氢姜黄素的抗癌特性的研究，并描述了其作用机理。由于仅进行了有限的药代动力学和口服生物利用度研究，因此尚未评估四氢姜黄素的效用。这篇综述总结了关于四氢姜黄素的抗癌特性的研究，并描述了其作用机理。由于仅进行了有限的药代动力学和口服生物利用度研究，因此尚未评估四氢姜黄素的效用。这篇综述总结了关于四氢姜黄素的抗癌特性的研究，并描述了其作用机理。