Polyphenols have been extensively studied due to their beneficial effects on human health, particularly for the prevention and treatment of diseases related to oxidative stress. Nevertheless, they are also known to have an anti-nutritional effect in relation to protein metabolism. This effect is a consequence of its binding to digestive enzymes and/or protein substrates. Dietary gluten is the main trigger of celiac disease, a common immune-based disease of the small intestine and for which the only treatment available is the adherence to a gluten-free diet. Recent studies have addressed the use of dietary polyphenols to interact with gluten proteins and avoid its downstream deleterious effects, taking the advantage of the anti-nutritive nature of polyphenols by protein sequestering. Flavonoids, coumarins and tannins have shown the ability to form insoluble complexes with gluten proteins. One of the most promising molecules has been epigallocatechin-3-gallate, which through its binding to gliadins, was able to reduce gliadins digestibility and its ability to stimulate monolayer permeability and transepithelial transport of immunodominant peptides in cell models. This review focuses on the structural features and binding capacity of polyphenols to gluten proteins and peptides, and the prospects of developing an adjuvant therapy in celiac disease.

中文翻译：

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审查结构特征和多酚对麸质蛋白和肽的体外结合能力：与乳糜泻的相关性。

由于多酚对人体健康，特别是对与氧化应激有关的疾病的预防和治疗具有有益作用，因此已进行了广泛的研究。尽管如此，还已知它们在蛋白质代谢方面具有抗营养作用。该作用是其与消化酶和/或蛋白质底物结合的结果。饮食中的麸质是导致腹腔疾病的主要诱因，后者是一种常见的基于免疫的小肠疾病，唯一的治疗方法是坚持无麸质饮食。最近的研究已经解决了利用膳食多酚与面筋蛋白相互作用并避免其下游有害作用的问题，并利用了蛋白质螯合多酚的抗营养特性。类黄酮，香豆素和丹宁酸已显示出与面筋蛋白形成不溶性复合物的能力。最有前途的分子之一是表没食子儿茶素-3-没食子酸酯，它通过与麦醇溶蛋白结合，能够降低麦醇溶蛋白的消化率，并能刺激细胞模型中免疫显性肽的单层通透性和上皮运输。这篇综述着重于多酚与面筋蛋白和肽的结构特征和结合能力，以及在乳糜泻中开发辅助疗法的前景。能够降低麦醇溶蛋白的消化率及其刺激细胞模型中免疫优势肽的单层通透性和上皮运输的能力。这篇综述着重于多酚与面筋蛋白和肽的结构特征和结合能力，以及在乳糜泻中开发辅助疗法的前景。能够降低麦醇溶蛋白的消化率及其刺激细胞模型中免疫优势肽的单层通透性和上皮运输的能力。这篇综述着重于多酚与面筋蛋白和肽的结构特征和结合能力，以及在乳糜泻中开发辅助疗法的前景。