当前位置: X-MOL 学术J. Cell. Mol. Med. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Resolvin D1 and D2 inhibit tumour growth and inflammation via modulating macrophage polarization.
Journal of Cellular and Molecular Medicine ( IF 5.3 ) Pub Date : 2020-05-29 , DOI: 10.1111/jcmm.15436
Kai Shan 1, 2 , Ninghan Feng 3 , Jing Cui 1, 2 , Shunhe Wang 2 , Hongyan Qu 1, 2 , Guoling Fu 1, 2 , Jiaqi Li 1, 2 , Heyan Chen 1, 2 , Xiaoying Wang 1 , Rong Wang 1, 2 , Yumin Qi 1, 2 , Zhennan Gu 2 , Yong Q Chen 1, 2
Affiliation  

Plastic polarization of macrophage is involved in tumorigenesis. M1‐polarized macrophage mediates rapid inflammation, entity clearance and may also cause inflammation‐induced mutagenesis. M2‐polarized macrophage inhibits rapid inflammation but can promote tumour aggravation. ω‐3 long‐chain polyunsaturated fatty acid (PUFA)‐derived metabolites show a strong anti‐inflammatory effect because they can skew macrophage polarization from M1 to M2. However, their role in tumour promotive M2 macrophage is still unknown. Resolvin D1 and D2 (RvD1 and RvD2) are docosahexaenoic acid (DHA)‐derived docosanoids converted by 15‐lipoxygenase then 5‐lipoxygenase successively. We found that although dietary DHA can inhibit prostate cancer in vivo, neither DHA (10 μmol/L) nor RvD (100 nmol/L) can directly inhibit the proliferation of prostate cancer cells in vitro. Unexpectedly, in a cancer cell‐macrophage co‐culture system, both DHA and RvD significantly inhibited cancer cell proliferation. RvD1 and RvD2 inhibited tumour‐associated macrophage (TAM or M2d) polarization. Meanwhile, RvD1 and RvD2 also exhibited anti‐inflammatory effects by inhibiting LPS‐interferon (IFN)‐γ‐induced M1 polarization as well as promoting interleukin‐4 (IL‐4)‐mediated M2a polarization. These differential polarization processes were mediated, at least in part, by protein kinase A. These results suggest that regulation of macrophage polarization using RvDs may be a potential therapeutic approach in the management of prostate cancer.

中文翻译:

Resolvin D1和D2通过调节巨噬细胞极化来抑制肿瘤生长和炎症。

巨噬细胞的塑性极化与肿瘤发生有关。M1极化的巨噬细胞介导快速炎症,实体清除,还可能引起炎症诱导的诱变。M2极化的巨噬细胞可抑制快速炎症,但可促进肿瘤加重。ω-3长链多不饱和脂肪酸(PUFA)衍生的代谢产物具有很强的抗炎作用,因为它们可以使巨噬细胞的极化从M1偏向M2。然而,它们在肿瘤促进M2巨噬细胞中的作用仍是未知的。Resolvin D1和D2(RvD1和RvD2)是二十二碳六烯酸(DHA)衍生的二十二碳六烯酸,依次被15-脂氧合酶和5-脂氧合酶转化。我们发现,尽管饮食中的DHA可以体内抑制前列腺癌,但DHA(10μmol/ L)和RvD(100 nmol / L)都不能直接抑制体外前列腺癌细胞的增殖。出乎意料的是,在癌细胞-巨噬细胞共培养系统中,DHA和RvD都显着抑制了癌细胞的增殖。RvD1和RvD2抑制了肿瘤相关巨噬细胞(TAM或M2d)的极化。同时,RvD1和RvD2还通过抑制LPS-干扰素(IFN)-γ诱导的M1极化并促进白介素4(IL-4)介导的M2a极化而表现出抗炎作用。这些差异极化过程至少部分地由蛋白激酶A介导。这些结果表明,使用RvDs调节巨噬细胞极化可能是治疗前列腺癌的潜在治疗方法。同时,RvD1和RvD2还通过抑制LPS-干扰素(IFN)-γ诱导的M1极化并促进白介素4(IL-4)介导的M2a极化而表现出抗炎作用。这些差异极化过程至少部分地由蛋白激酶A介导。这些结果表明,使用RvDs调节巨噬细胞极化可能是治疗前列腺癌的潜在治疗方法。同时,RvD1和RvD2还通过抑制LPS-干扰素(IFN)-γ诱导的M1极化并促进白介素4(IL-4)介导的M2a极化而表现出抗炎作用。这些差异极化过程至少部分地由蛋白激酶A介导。这些结果表明,使用RvDs调节巨噬细胞极化可能是治疗前列腺癌的潜在治疗方法。
更新日期:2020-07-10
down
wechat
bug