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Hypoxia-induced pulmonary hypertension-Utilizing experiments of nature.
British Journal of Pharmacology ( IF 7.3 ) Pub Date : 2020-05-28 , DOI: 10.1111/bph.15144
Max Gassmann 1, 2 , Andrew Cowburn 3 , Hong Gu 4 , Jia Li 5 , Marisela Rodriguez 6 , Aleksandra Babicheva 6 , Pritesh P Jain 6 , Mingmei Xiong 6 , Norina N Gassmann 1 , Jason X-J Yuan 6 , Martin R Wilkins 3 , Lan Zhao 3
Affiliation  

An increase in pulmonary artery pressure is a common observation in adult mammals exposed to global alveolar hypoxia. It is considered a maladaptive response that places an increased workload on the right ventricle. The mechanisms initiating and maintaining the elevated pressure are of considerable interest in understanding pulmonary vascular homeostasis. There is an expectation that identifying the key molecules in the integrated vascular response to hypoxia will inform potential drug targets. One strategy is to take advantage of experiments of nature, specifically, to understand the genetic basis for the inter‐individual variation in the pulmonary vascular response to acute and chronic hypoxia. To date, detailed phenotyping of highlanders has focused on haematocrit and oxygen saturation rather than cardiovascular phenotypes. This review explores what we can learn from those studies with respect to the pulmonary circulation.

中文翻译:

缺氧性肺动脉高压-利用自然实验。

肺动脉压升高是暴露于全球肺泡缺氧的成年哺乳动物的常见观察结果。它被认为是一种不适应的反应,会增加右心室的工作量。启动和维持高压的机制对于理解肺血管稳态具有相当大的意义。预计识别缺氧综合血管反应中的关键分子将为潜在的药物靶点提供信息。一种策略是利用自然实验,特别是了解肺血管对急性和慢性缺氧反应的个体间差异的遗传基础。迄今为止,高地人的详细表型分析主要集中在血细胞比容和氧饱和度,而不是心血管表型。
更新日期:2020-05-28
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