We examined the relationships between sleep and inflammatory biomarkers during late pregnancy. Seventy-four women underwent an overnight sleep assessment by polysomnography. Blood samples were collected before bedtime and again within 1 h upon awakening to measure C-reactive protein (CRP), interleukin (IL)-6, and IL-6 soluble receptor. Sleep parameters included variables characterizing sleep architecture and sleep continuity. The participants were 32.2 (SD = 4.1) years old, and the average gestational age was 32.8 (3.5) weeks. Controlling for covariates, evening CRP was negatively associated with N3 sleep (β = -0.30, P = 0.010). N3 sleep was also negatively associated with morning CRP (β = -0.26, P = 0.036), with a higher percentage of N3 sleep associated with a lower level of morning CRP. Contrarily, there was a tendency for a positive association between stage N2 sleep and morning CRP (β = 0.23, P = 0.065). Stage N1 sleep was associated with morning IL-6 (β = 0.28, P = 0.021), with a higher percentage of N1 sleep associated with a higher morning IL-6. No significant associations were found between morning inflammatory biomarkers and sleep continuity parameters. In conclusion, increased light sleep was associated with increased inflammatory biomarkers, whereas more deep sleep was associated with decreased inflammatory biomarkers. These findings further support the interactions between sleep and the immune system during late pregnancy.

中文翻译：

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妊娠期客观睡眠参数与炎症生物标志物的关系

我们检查了妊娠晚期睡眠和炎症生物标志物之间的关系。74 名女性通过多导睡眠图进行了夜间睡眠评估。在睡前和醒来后 1 小时内再次采集血样，以测量 C 反应蛋白 (CRP)、白细胞介素 (IL)-6 和 IL-6 可溶性受体。睡眠参数包括表征睡眠结构和睡眠连续性的变量。参与者年龄为 32.2 (SD = 4.1) 岁，平均胎龄为 32.8 (3.5) 周。控制协变量，晚间 CRP 与 N3 睡眠呈负相关（β = -0.30，P = 0.010）。N3 睡眠也与早晨 CRP 呈负相关（β = -0.26，P = 0.036），N3 睡眠的百分比较高与较低水平的早晨 CRP 相关。相反，N2 期睡眠与早晨 CRP 之间存在正相关趋势（β = 0.23，P = 0.065）。N1 期睡眠与早晨 IL-6 相关（β = 0.28，P = 0.021），N1 睡眠的百分比较高与较高的早晨 IL-6 相关。没有发现早晨炎症生物标志物与睡眠连续性参数之间存在显着关联。总之，轻度睡眠的增加与炎症生物标志物的增加有关，而更深的睡眠与炎症生物标志物的减少有关。这些发现进一步支持了妊娠晚期睡眠与免疫系统之间的相互作用。没有发现早晨炎症生物标志物与睡眠连续性参数之间存在显着关联。总之，轻度睡眠的增加与炎症生物标志物的增加有关，而更深的睡眠与炎症生物标志物的减少有关。这些发现进一步支持了妊娠晚期睡眠与免疫系统之间的相互作用。没有发现早晨炎症生物标志物与睡眠连续性参数之间存在显着关联。总之，轻度睡眠的增加与炎症生物标志物的增加有关，而更深的睡眠与炎症生物标志物的减少有关。这些发现进一步支持了妊娠晚期睡眠与免疫系统之间的相互作用。