Coronavirus Disease 2019 (COVID-19) is an ongoing public health emergency and new knowledge about its immunopathogenic mechanisms is deemed necessary in the attempt to reduce the death burden, globally. For the first time in worldwide literature, we provide scientific evidence that in COVID-19 vasculitis a life-threatening escalation from type 2 T-helper immune response (humoral immunity) to type 3 hypersensitivity (immune complex disease) takes place. The subsequent deposition of immune complexes inside the vascular walls is supposed to induce a severe inflammatory state and a cytokine release syndrome, whose interleukin-6 is the key myokine, from the smooth muscle cells of blood vessels.

2019 年冠状病毒病 (COVID-19) 是一种持续的突发公共卫生事件，有关其免疫致病机制的新知识被认为是减少全球死亡负担的必要措施。在全球文献中，我们首次提供科学证据表明，在 COVID-19 血管炎中，会发生从 2 型 T 辅助免疫反应（体液免疫）到 3 型超敏反应（免疫复合物疾病）的危及生命的升级。免疫复合物随后沉积在血管壁内，据推测会从血管的平滑肌细胞中诱发严重的炎症状态和细胞因子释放综合征，其白细胞介素 6 是关键的肌因子。