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The choice of anti-tumor strategies based on micromolecules or drug loading function of biomaterials.
Cancer Letters ( IF 9.7 ) Pub Date : 2020-05-29 , DOI: 10.1016/j.canlet.2020.05.019
Chengyi Liu 1 , Tianke Zhang 2 , Liqun Chen 3 , Yue Chen 4
Affiliation  

With advances in modern medicine, diverse tumor therapies have been developed. However, because of a lack of effective methods, the delivery of drugs or micromolecules in the human body has many limitations. Biomaterials are natural or synthetic functional materials that are prone to contact or interact with living systems. Therefore, the application of biomaterials provides innovative anti-tumor strategies, especially in tumor targeting, chemotherapy sensitization, tumor immunotherapy. The combination of biomaterials and drugs provides a promising strategy to overcome the biological barriers of drug delivery. Nanomaterials can target specific tumor sites to enhance the efficiency of tumor therapies and decrease the toxicity of drug through passive targeting, active targeting and direct targeting. Additionally, biomaterials can be used to enhance the sensitivity of tumor cells to chemotherapy drugs. Furthermore, modifiable biomaterials can induce effective anti-tumor immune response. Currently, the developmental trend of biomaterial for drug delivery is motivated by the combination and diversification of different therapies. With interdisciplinary development, a variety of anti-tumor strategies will emerge in an endless stream to bring great hope for tumor therapy. In this review, we will discuss the anti-tumor strategies based on nanoparticles and injectable scaffolds.



中文翻译:

基于小分子或生物材料载药功能的抗肿瘤策略的选择。

随着现代医学的进步,已经开发了多种肿瘤疗法。然而,由于缺乏有效的方法,药物或小分子在人体中的递送具有许多局限性。生物材料是易于​​与生物系统接触或相互作用的天然或合成功能材料。因此,生物材料的应用提供了创新的抗肿瘤策略,尤其是在肿瘤靶向,化学疗法致敏,肿瘤免疫疗法中。生物材料和药物的结合为克服药物输送的生物学障碍提供了一种有前途的策略。纳米材料可以通过被动靶向,主动靶向和直接靶向来靶向特定的肿瘤部位,从而提高肿瘤治疗的效率并降低药物的毒性。另外,生物材料可用于增强肿瘤细胞对化疗药物的敏感性。此外,可修饰的生物材料可以诱导有效的抗肿瘤免疫反应。当前,用于药物递送的生物材料的发展趋势是由不同疗法的组合和多样化推动的。随着学科的发展,各种各样的抗肿瘤策略将层出不穷,为肿瘤治疗带来巨大希望。在这篇综述中,我们将讨论基于纳米颗粒和可注射支架的抗肿瘤策略。随着学科的发展,各种各样的抗肿瘤策略将层出不穷,为肿瘤治疗带来巨大希望。在这篇综述中,我们将讨论基于纳米颗粒和可注射支架的抗肿瘤策略。随着学科的发展,各种各样的抗肿瘤策略将层出不穷,为肿瘤治疗带来巨大希望。在这篇综述中,我们将讨论基于纳米颗粒和可注射支架的抗肿瘤策略。

更新日期:2020-05-29
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