Abstract The densities of three pharmacologically significantly used drugs i.e., Chloroquine phosphate (CP), Acefylline piperazine (AP) and Gentamicin sulfate (GS) have been carried out in aqueous (aq), aqueous polyethylene glycol (aq-PEG) and aqueous polyvinyl pyrrolidone (aq-PVP) solvent systems within concentration range (0.02–0.1 ± 0.001 mol.dm−3) at different temperatures (293.15–318.15 K) with the interval of 5 K. Density data were used to evaluate volumetric properties of drugs (CP, AP and GS) by apparent molar volume, partial molar volumes, molar expansibilities and isothermal expansion coefficient. ϕ E ° provides information about the absence or presence of a caging or packing effect. Partial molar transfer volume was also calculated to study the hydrophilic/hydrophobic interactions in aq-PEG and aq-PVP solvent systems. The results are interpreted in terms of drug–solvent and drug-drug interactions and structure making or breaking abilities of drugs in aq, aq-PEG and aq-PVP solvent systems.

中文翻译：

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磷酸氯喹、乙酰茶碱哌嗪和硫酸庆大霉素在聚合物体系中的药物-药物和药物-溶剂相互作用研究

摘要 磷酸氯喹 (CP)、乙酰茶碱哌嗪 (AP) 和硫酸庆大霉素 (GS) 三种药理学显着使用的药物的密度已在水性 (aq)、水性聚乙二醇 (aq-PEG) 和水性聚乙烯吡咯烷酮中进行。 (aq-PVP) 溶剂系统在浓度范围 (0.02–0.1 ± 0.001 mol.dm-3) 下在不同温度 (293.15–318.15 K) 下间隔 5 K。密度数据用于评估药物的体积特性 (CP , AP 和 GS) 由表观摩尔体积、偏摩尔体积、摩尔膨胀率和等温膨胀系数决定。ϕ E ° 提供有关是否存在笼养或填充效应的信息。还计算了部分摩尔转移体积以研究 aq-PEG 和 aq-PVP 溶剂系统中的亲水/疏水相互作用。