Hydrogen therapy has recently emerged as an attractive approach for combating major diseases including cancer, diabetes, stroke and Parkinson's disease. Herein, we ingeniously fabricated a fully biodegradable Magnesium (Mg) based micromotor for the active hydrogen and chemotherapeutics delivery, and firstly proposed the concept of a self-propelled micromotor platform used for cancer active hydrogen-chemotherapy. By consuming water, the micromotor generates sufficient hydrogen in-situ, which is not only propellant for motion, but also active component for hydrogen therapy. The active motion of micromotors with a speed up to 57 ± 19 μm•s⁻¹ leads to enhanced diffusion of produced hydrogen that allows for higher extracellular and intracellular reducibility. Compared with the non-motor control, the micromotor loaded with doxorubicin improves the chemotherapy efficacy significantly by 2.4 times for 4T1 tumor cells with a concentration as low as 100 μg•mL⁻¹. These results indicate that the Mg-based micromotors can act as self-propelled carriers for enhanced intracellular hydrogen and cancer chemotherapy. Taking advantage of the locally hydrogen generation and the active moving capabilities, the facilely engineered Mg micromotor provides great promise for cancer synergistic hydrogen chemotherapy.

氢疗法最近作为一种抗击重大疾病的有吸引力方法，包括癌症，糖尿病，中风和帕金森氏病。在这里，我们巧妙地制造了一种完全可生物降解的基于镁（Mg）的微电机，用于活性氢和化学疗法的输送，并首先提出了一种用于癌症活性氢化学疗法的自推进式微电机平台的概念。通过消耗水，微电机就地产生足够的氢，氢不仅是运动的推进剂，还是氢疗法的活性成分。微型电机的主动运动，速度高达57±19μm• s ^{− 1}导致产生的氢扩散增强，从而使细胞外和细胞内具有更高的还原性。与非运动控制相比，阿霉素微电机对浓度低至100μg•mL ^-1的4T1肿瘤细胞的化疗疗效显着提高了2.4倍。这些结果表明，基于镁的微电机可以作为自推进载体，用于增强细胞内氢和癌症化学疗法。利用局部氢气产生和主动运动的能力，轻巧设计的Mg微电机为癌症协同氢气化疗提供了广阔前景。