A current trend in modern bioinformatics is representation of nucleotide sequences in the form of gene-based (GB) speckles. In this letter GB-speckles have been processed using the s-LASCA (laser speckle contrast analysis) technique. Statistical properties of s-LASCA images of GB-speckles have been analyzed. It is shown that application of the s-LASCA technique allows us to essentially increase the the sensitivity of detection of a single nucleotide polymorphism using GB-speckles.

中文翻译：

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基于基因斑点的LASCA成像：在细菌模型中检测基因多态性的应用

现代生物信息学的当前趋势是以核苷酸（GB）斑点形式表示核苷酸序列。在这封信中，已使用s-LASCA（激光斑点对比分析）技术处理了GB斑点。分析了GB斑点的s-LASCA图像的统计特性。结果表明，s-LASCA技术的应用使我们从本质上提高了使用GB斑点检测单核苷酸多态性的灵敏度。