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Diacylglycerol-evoked activation of PKC and PKD isoforms in regulation of glucose and lipid metabolism: a review.
Lipids in Health and Disease ( IF 4.5 ) Pub Date : 2020-05-28 , DOI: 10.1186/s12944-020-01286-8
Katarzyna Kolczynska 1 , Angel Loza-Valdes 1 , Izabela Hawro 1 , Grzegorz Sumara 1
Affiliation  

Protein kinase C (PKC) and Protein kinase D (PKD) isoforms can sense diacylglycerol (DAG) generated in the different cellular compartments in various physiological processes. DAG accumulates in multiple organs of the obese subjects, which leads to the disruption of metabolic homeostasis and the development of diabetes as well as associated diseases. Multiple studies proved that aberrant activation of PKCs and PKDs contributes to the development of metabolic diseases. DAG-sensing PKC and PKD isoforms play a crucial role in the regulation of metabolic homeostasis and therefore might serve as targets for the treatment of metabolic disorders such as obesity and diabetes.

中文翻译:

二酰基甘油诱发的PKC和PKD同工型在葡萄糖和脂质代谢调节中的激活:综述。

蛋白激酶C(PKC)和蛋白激酶D(PKD)同工型可以感知在各种生理过程中在不同细胞区室中生成的二酰基甘油(DAG)。DAG累积在肥胖受试者的多个器官中,这导致代谢稳态的破坏和糖尿病以及相关疾病的发展。多项研究证明,PKC和PKD的异常激活有助于代谢性疾病的发展。DAG感测的PKC和PKD同工型在代谢代谢稳态的调节中起着至关重要的作用,因此可以作为治疗肥胖症和糖尿病等代谢性疾病的靶标。
更新日期:2020-05-28
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