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Development and Execution of a Production-Scale Continuous [2 + 2] Photocycloaddition
Organic Process Research & Development ( IF 3.4 ) Pub Date : 2020-05-27 , DOI: 10.1021/acs.oprd.0c00185
Matthew G. Beaver 1 , En-xuan Zhang 2 , Zhi-qing Liu 2 , Song-yuan Zheng 2 , Bin Wang 2 , Jiang-ping Lu 2 , Jian Tao 2 , Miguel Gonzalez 2 , Siân Jones 3 , Jason S. Tedrow 1
Affiliation  

This article details the approach to large-scale production of cyclobutane 2 by the continuous-flow [2 + 2] photocycloaddition of maleic anhydride and ethylene, including (1) focused reaction optimization and development of a robust isolation protocol, (2) the approach to equipment design and process safety, and (3) the results of commissioning tests and production runs delivering the target compound at throughputs exceeding 5 kg/day.

中文翻译:

大规模生产[2 + 2]连续光环加成反应的开发和执行

本文详细介绍了通过连续流动[2 + 2]马来酸酐和乙烯的光环加成反应大规模生产环丁烷2的方法,其中包括(1)重点优化反应和开发可靠的分离方案,(2)方法设备设计和过程安全;以及(3)调试测试和生产运行的结果,以超过5千克/天的产量提供目标化合物。
更新日期:2020-05-27
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