Large-scale sequencing projects provide high-quality full-genome data that can be used for reconstruction of chromosomal exchanges and rearrangements that disrupt conserved syntenic blocks. The highest resolution of cross-species homology can be obtained on the basis of whole-genome, reference-free alignments. Very large multiple alignments of full-genome sequence stored in a binary format demand an accurate and efficient computational approach for synteny block production.

中文翻译：

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halSynteny：一种快速、易于使用的保守同线性块构建方法，用于多个全基因组比对。

大规模测序项目提供高质量的全基因组数据，可用于重建破坏保守同线块的染色体交换和重排。在全基因组、无参考比对的基础上，可以获得最高分辨率的跨物种同源性。以二进制格式存储的全基因组序列的非常大的多重比对需要一种准确和高效的计算方法来生产同线性块。