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Valproic acid-labeled chitosan nanoparticles promote recovery of neuronal injury after spinal cord injury.
Aging-US ( IF 5.2 ) Pub Date : 2020-05-28 , DOI: 10.18632/aging.103125
Dimin Wang 1, 2 , Kai Wang 3 , Zhenlei Liu 3 , Zonglin Wang 1 , Hao Wu 3
Affiliation  

Chitosan nanoparticles have been recognized as a new type of biomaterials for treatment of spinal cord injury (SCI). To develop a novel treatment method targeted delivery injured spinal cord, valproic acid labeled chitosan nanoparticles (VA-CN) were constructed and evaluated in the treatment of SCI. Our results demonstrated that administration of VA-CN significantly promoted the recovery of the function and tissue repair after SCI. Moreover, we found treatment of VA-CN inhibited the reactive astrocytes after SCI. Furthermore, administration of VA-CN enhanced immunoreactions of neuronal related marker NF160, which suggested that VA-CN could promote the neuroprotective function in rats of SCI. The production of IL-1β, IL-6 and TNF-α were significantly decreased following treatment of VA-CN. Meanwhile, administration of VA-CN effectively improved the blood spinal cord barrier (BSCB) disruption after SCI. Administration of VA-CN could enhance the recovery of neuronal injury, suppress the reactive astrocytes and inflammation, and improve the blood spinal cord barrier disruption after SCI in rats. These results provided a novel and promising therapeutic manner for SCI.

中文翻译:

丙戊酸标记的壳聚糖纳米颗粒促进脊髓损伤后神经元损伤的恢复。

壳聚糖纳米颗粒已被公认为治疗脊髓损伤(SCI)的新型生物材料。为了开发一种新的靶向递送损伤脊髓的治疗方法,构建并评估了丙戊酸标记的壳聚糖纳米颗粒(VA-CN)在 SCI 治疗中的作用。我们的结果表明,VA-CN 的施用显着促进了 SCI 后功能的恢复和组织修复。此外,我们发现 VA-CN 的治疗抑制了 SCI 后的反应性星形胶质细胞。此外,VA-CN 的给药增强了神经元相关标志物 NF160 的免疫反应,这表明 VA-CN 可以促进 SCI 大鼠的神经保护功能。VA-CN 治疗后 IL-1β、IL-6 和 TNF-α 的产生显着降低。同时,VA-CN 的给药有效地改善了 SCI 后血脊髓屏障 (BSCB) 的破坏。给予 VA-CN 可促进神经元损伤的恢复,抑制反应性星形胶质细胞和炎症,改善大鼠 SCI 后血脊髓屏障的破坏。这些结果为 SCI 提供了一种新颖且有前景的治疗方法。
更新日期:2020-05-28
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